Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection

Hema Manjunath, He Zhang, Frederick Rehfeld, Jaeil Han, Tsung Cheng Chang, Joshua T. Mendell

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Translation initiation codon selection is a highly regulated process that can influence the sequence and activity of a translated protein. Here, Manjunath et al. demonstrate that loss of the translation elongation factor eIF5A triggers widespread translation initiation in 5′ UTRs, uncovering a role for this protein in start codon selection.

Original languageEnglish (US)
Pages (from-to)3134-3146.e6
JournalCell Reports
Volume29
Issue number10
DOIs
StatePublished - Dec 3 2019

Keywords

  • 5’ untranslated region
  • eIF5A
  • MYC
  • ribosomal pausing
  • ribosome profiling
  • translation initiation
  • upstream translation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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