Suprasellar germinomas (ectopic pinealomas)

Aspects of immunological characterization and successful chemotherapeutic responses in recurrent disease

E. A. Neuwelt, E. P. Frenkel, R. G. Smith

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Two patients with suprasellar germinomas were initially treated successfully with radiotherapy, but subsequently they developed recurrent tumor 2 1/2 and 12 years later. The recurrent tumor was solely extraneural in the first patient because of seeding from a ventriculoperitoneal shunt, and in the second patient the tumor recurred at its initial site as well as in the 4th ventricle. Both tumors secreted the β-subunit of human chorionic gonadotropin. A dramatic tumor response was seen in both patients with systemic chemotherapy consisting of a combination of cis-platinum, bleomycin, and vinblastine. The 'small cells' in one of the suprasellar germinomas were shown to be predominately T lymphocytes on the basis of an examination of the cell surface markers on these cells.

Original languageEnglish (US)
Pages (from-to)352-358
Number of pages7
JournalNeurosurgery
Volume7
Issue number4
StatePublished - 1980

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Germinoma
Pinealoma
Neoplasms
Fourth Ventricle
Ventriculoperitoneal Shunt
Vinblastine
Bleomycin
Chorionic Gonadotropin
Cisplatin
Radiotherapy
T-Lymphocytes
Drug Therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Suprasellar germinomas (ectopic pinealomas) : Aspects of immunological characterization and successful chemotherapeutic responses in recurrent disease. / Neuwelt, E. A.; Frenkel, E. P.; Smith, R. G.

In: Neurosurgery, Vol. 7, No. 4, 1980, p. 352-358.

Research output: Contribution to journalArticle

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