Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties

P. R. Bergstresser, C. R. Fletcher, J. W. Streilein

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Epidermal Langerhans cells bear surface receptors which implicate them as immunocompetent cells and they are now felt to play an important role both in delayed hypersensitivity and in skin allograft reactions. To determine the relationship between Langerhans cell availability and certain immunologic phenomena, surface densities were determined by ATP-ase and gold uptake in 3 rodent species: guinea pig, hamster, and mouse. Surface densities in epidermal specimens from the ear, back, foot pad, and buccal mucosa varied between 60 and 1500 cells/mm2. Significantly fewer cells were found in the hamster cheek pouch (130 cells/mm2) and in the mouse tail (110 cells/mm2 for C57BL/6J; 260 cells/mm2 for BALB/c nu/nu). Langerhans cells were absent from the central portion of the cornea in all 3 species. Decreased Langerhans cell surface density may contribute to immunologic privilege as has been observed for the cornea and hamster cheek pouch and to the unusual allograft characteristics of mouse tail skin.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalJournal of Investigative Dermatology
Volume74
Issue number2
StatePublished - 1980

Fingerprint

Langerhans Cells
Allografts
Rodentia
Skin
Surface phenomena
Cell Surface Receptors
Cricetinae
Gold
Cheek
Availability
Cornea
Tail
Delayed Hypersensitivity
Mouth Mucosa
Ear
Foot
Guinea Pigs
Cell Count
Adenosine Triphosphate
Mucous Membrane

ASJC Scopus subject areas

  • Dermatology

Cite this

Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties. / Bergstresser, P. R.; Fletcher, C. R.; Streilein, J. W.

In: Journal of Investigative Dermatology, Vol. 74, No. 2, 1980, p. 77-80.

Research output: Contribution to journalArticle

Bergstresser, P. R. ; Fletcher, C. R. ; Streilein, J. W. / Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties. In: Journal of Investigative Dermatology. 1980 ; Vol. 74, No. 2. pp. 77-80.
@article{4ff6dd6a24fa4094a67b0d31669c87fb,
title = "Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties",
abstract = "Epidermal Langerhans cells bear surface receptors which implicate them as immunocompetent cells and they are now felt to play an important role both in delayed hypersensitivity and in skin allograft reactions. To determine the relationship between Langerhans cell availability and certain immunologic phenomena, surface densities were determined by ATP-ase and gold uptake in 3 rodent species: guinea pig, hamster, and mouse. Surface densities in epidermal specimens from the ear, back, foot pad, and buccal mucosa varied between 60 and 1500 cells/mm2. Significantly fewer cells were found in the hamster cheek pouch (130 cells/mm2) and in the mouse tail (110 cells/mm2 for C57BL/6J; 260 cells/mm2 for BALB/c nu/nu). Langerhans cells were absent from the central portion of the cornea in all 3 species. Decreased Langerhans cell surface density may contribute to immunologic privilege as has been observed for the cornea and hamster cheek pouch and to the unusual allograft characteristics of mouse tail skin.",
author = "Bergstresser, {P. R.} and Fletcher, {C. R.} and Streilein, {J. W.}",
year = "1980",
language = "English (US)",
volume = "74",
pages = "77--80",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties

AU - Bergstresser, P. R.

AU - Fletcher, C. R.

AU - Streilein, J. W.

PY - 1980

Y1 - 1980

N2 - Epidermal Langerhans cells bear surface receptors which implicate them as immunocompetent cells and they are now felt to play an important role both in delayed hypersensitivity and in skin allograft reactions. To determine the relationship between Langerhans cell availability and certain immunologic phenomena, surface densities were determined by ATP-ase and gold uptake in 3 rodent species: guinea pig, hamster, and mouse. Surface densities in epidermal specimens from the ear, back, foot pad, and buccal mucosa varied between 60 and 1500 cells/mm2. Significantly fewer cells were found in the hamster cheek pouch (130 cells/mm2) and in the mouse tail (110 cells/mm2 for C57BL/6J; 260 cells/mm2 for BALB/c nu/nu). Langerhans cells were absent from the central portion of the cornea in all 3 species. Decreased Langerhans cell surface density may contribute to immunologic privilege as has been observed for the cornea and hamster cheek pouch and to the unusual allograft characteristics of mouse tail skin.

AB - Epidermal Langerhans cells bear surface receptors which implicate them as immunocompetent cells and they are now felt to play an important role both in delayed hypersensitivity and in skin allograft reactions. To determine the relationship between Langerhans cell availability and certain immunologic phenomena, surface densities were determined by ATP-ase and gold uptake in 3 rodent species: guinea pig, hamster, and mouse. Surface densities in epidermal specimens from the ear, back, foot pad, and buccal mucosa varied between 60 and 1500 cells/mm2. Significantly fewer cells were found in the hamster cheek pouch (130 cells/mm2) and in the mouse tail (110 cells/mm2 for C57BL/6J; 260 cells/mm2 for BALB/c nu/nu). Langerhans cells were absent from the central portion of the cornea in all 3 species. Decreased Langerhans cell surface density may contribute to immunologic privilege as has been observed for the cornea and hamster cheek pouch and to the unusual allograft characteristics of mouse tail skin.

UR - http://www.scopus.com/inward/record.url?scp=0018890938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018890938&partnerID=8YFLogxK

M3 - Article

C2 - 6985948

AN - SCOPUS:0018890938

VL - 74

SP - 77

EP - 80

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 2

ER -