Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties

P. R. Bergstresser, C. R. Fletcher, J. W. Streilein

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Epidermal Langerhans cells bear surface receptors which implicate them as immunocompetent cells and they are now felt to play an important role both in delayed hypersensitivity and in skin allograft reactions. To determine the relationship between Langerhans cell availability and certain immunologic phenomena, surface densities were determined by ATP-ase and gold uptake in 3 rodent species: guinea pig, hamster, and mouse. Surface densities in epidermal specimens from the ear, back, foot pad, and buccal mucosa varied between 60 and 1500 cells/mm2. Significantly fewer cells were found in the hamster cheek pouch (130 cells/mm2) and in the mouse tail (110 cells/mm2 for C57BL/6J; 260 cells/mm2 for BALB/c nu/nu). Langerhans cells were absent from the central portion of the cornea in all 3 species. Decreased Langerhans cell surface density may contribute to immunologic privilege as has been observed for the cornea and hamster cheek pouch and to the unusual allograft characteristics of mouse tail skin.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalJournal of Investigative Dermatology
Volume74
Issue number2
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Fingerprint Dive into the research topics of 'Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties'. Together they form a unique fingerprint.

  • Cite this