@article{4ff6dd6a24fa4094a67b0d31669c87fb,
title = "Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties",
abstract = "Epidermal Langerhans cells bear surface receptors which implicate them as immunocompetent cells and they are now felt to play an important role both in delayed hypersensitivity and in skin allograft reactions. To determine the relationship between Langerhans cell availability and certain immunologic phenomena, surface densities were determined by ATP-ase and gold uptake in 3 rodent species: guinea pig, hamster, and mouse. Surface densities in epidermal specimens from the ear, back, foot pad, and buccal mucosa varied between 60 and 1500 cells/mm2. Significantly fewer cells were found in the hamster cheek pouch (130 cells/mm2) and in the mouse tail (110 cells/mm2 for C57BL/6J; 260 cells/mm2 for BALB/c nu/nu). Langerhans cells were absent from the central portion of the cornea in all 3 species. Decreased Langerhans cell surface density may contribute to immunologic privilege as has been observed for the cornea and hamster cheek pouch and to the unusual allograft characteristics of mouse tail skin.",
author = "Bergstresser, {P. R.} and Fletcher, {C. R.} and Streilein, {J. W.}",
note = "Funding Information: In 1973, Silberberg identified lymphocytes in direct contact with Langerhans cells in sites of allergic contact dermatitis reactions and suggested that Langerhans cells might play a role in the development of delayed contact hypersensitivity [1]. Silberberg and her associates then traced the movement of antigen-bearing Langerhans cells from the dermis, where ferritin had been injected, to dermal lymphatics, ultimately reaching the draining regional lymph nodes [9-11]. Subsequently, Shelly and Juhlin observed in vitro a preferential accumulation of each of 10 different sensitizing materials within the Langerhans cells of epidermal whole mounts [12]. A series of recent studies now identify Langerhans cells as having functional characteristics of macro phages. Human Langer hans cells bear Fe and C3 receptors [13]. They take up and degrade exogenously applied Manuscript received May 31, 1979; accepted for publication August 8, 1979. This work was supported in part by U.S.P.H.S. Grants CA-09082, EY03119, AI-10679 and by a grant from the Dermatology Foundation. Reprint requests to: Paul R. Bergstresser, M.D., Division of Dermatology, University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75235.",
year = "1980",
doi = "10.1111/1523-1747.ep12519909",
language = "English (US)",
volume = "74",
pages = "77--80",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "2",
}