Surface simulation synthesis: A new strategy to spy α-helix structure

Xiao Nan Dong, Yu Chen, Ying Hua Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In key proteins, there are always some α-helix structures, which play important role in the structure and functions. Many epitopes lie on the surface of α-helix. These epitopes are not easy to be recruited into the vaccine development, because they are conformation dependent epitopes. Can such epitopes on α-helix be mimicked synthetically? Our findings undoubtedly validate the feasibility of surface simulation synthesis with short linear peptide to mimic the antigenic side of α-helix structure.

Original languageEnglish (US)
Pages (from-to)6569-6571
Number of pages3
JournalVaccine
Volume25
Issue number36
DOIs
StatePublished - Sep 4 2007

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epitopes
Epitopes
synthesis
vaccine development
Vaccines
peptides
Peptides
Proteins
proteins

Keywords

  • α-Helix
  • gp41
  • HIV-1
  • Surface simulation synthesis

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Surface simulation synthesis : A new strategy to spy α-helix structure. / Dong, Xiao Nan; Chen, Yu; Chen, Ying Hua.

In: Vaccine, Vol. 25, No. 36, 04.09.2007, p. 6569-6571.

Research output: Contribution to journalArticle

Dong, Xiao Nan ; Chen, Yu ; Chen, Ying Hua. / Surface simulation synthesis : A new strategy to spy α-helix structure. In: Vaccine. 2007 ; Vol. 25, No. 36. pp. 6569-6571.
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