Surface simulation synthesis: A new strategy to spy α-helix structure

Xiao Nan Dong; Yu Chen; Ying Hua Chen

doi:10.1016/j.vaccine.2006.09.064

Surface simulation synthesis: A new strategy to spy α-helix structure

Xiao Nan Dong, Yu Chen, Ying Hua Chen

Internal Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In key proteins, there are always some α-helix structures, which play important role in the structure and functions. Many epitopes lie on the surface of α-helix. These epitopes are not easy to be recruited into the vaccine development, because they are conformation dependent epitopes. Can such epitopes on α-helix be mimicked synthetically? Our findings undoubtedly validate the feasibility of surface simulation synthesis with short linear peptide to mimic the antigenic side of α-helix structure.

Original language	English (US)
Pages (from-to)	6569-6571
Number of pages	3
Journal	Vaccine
Volume	25
Issue number	36
DOIs	https://doi.org/10.1016/j.vaccine.2006.09.064
State	Published - Sep 4 2007

Keywords

α-Helix
gp41
HIV-1
Surface simulation synthesis

ASJC Scopus subject areas

Immunology
Microbiology
Virology
Infectious Diseases
Public Health, Environmental and Occupational Health
General Veterinary

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10.1016/j.vaccine.2006.09.064

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abstract = "In key proteins, there are always some α-helix structures, which play important role in the structure and functions. Many epitopes lie on the surface of α-helix. These epitopes are not easy to be recruited into the vaccine development, because they are conformation dependent epitopes. Can such epitopes on α-helix be mimicked synthetically? Our findings undoubtedly validate the feasibility of surface simulation synthesis with short linear peptide to mimic the antigenic side of α-helix structure.",

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AU - Chen, Ying Hua

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N2 - In key proteins, there are always some α-helix structures, which play important role in the structure and functions. Many epitopes lie on the surface of α-helix. These epitopes are not easy to be recruited into the vaccine development, because they are conformation dependent epitopes. Can such epitopes on α-helix be mimicked synthetically? Our findings undoubtedly validate the feasibility of surface simulation synthesis with short linear peptide to mimic the antigenic side of α-helix structure.

AB - In key proteins, there are always some α-helix structures, which play important role in the structure and functions. Many epitopes lie on the surface of α-helix. These epitopes are not easy to be recruited into the vaccine development, because they are conformation dependent epitopes. Can such epitopes on α-helix be mimicked synthetically? Our findings undoubtedly validate the feasibility of surface simulation synthesis with short linear peptide to mimic the antigenic side of α-helix structure.

KW - α-Helix

KW - gp41

KW - HIV-1

KW - Surface simulation synthesis

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ER -

Surface simulation synthesis: A new strategy to spy α-helix structure

Abstract

Keywords

ASJC Scopus subject areas

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