Surface simulation synthesis: A new strategy to spy α-helix structure

Xiao Nan Dong, Yu Chen, Ying Hua Chen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In key proteins, there are always some α-helix structures, which play important role in the structure and functions. Many epitopes lie on the surface of α-helix. These epitopes are not easy to be recruited into the vaccine development, because they are conformation dependent epitopes. Can such epitopes on α-helix be mimicked synthetically? Our findings undoubtedly validate the feasibility of surface simulation synthesis with short linear peptide to mimic the antigenic side of α-helix structure.

Original languageEnglish (US)
Pages (from-to)6569-6571
Number of pages3
Issue number36
StatePublished - Sep 4 2007


  • α-Helix
  • gp41
  • HIV-1
  • Surface simulation synthesis

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)


Dive into the research topics of 'Surface simulation synthesis: A new strategy to spy α-helix structure'. Together they form a unique fingerprint.

Cite this