Surgical approach and perioperative complications determine short-term outcomes in patients with insulinoma: Results of a bi-institutional study

Christina L. Roland, Chung Yau Lo, Barbra S. Miller, Shelby Holt, Fiemu E. Nwariaku

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30 Citations (Scopus)

Abstract

Background: Despite advancements in radiologic imaging and minimally invasive surgery, the evaluation and management of insulinomas is institution and surgeon dependent. Therefore, the reported surgical outcomes are highly variable. We compared the surgical management and outcomes of insulinomas between two international tertiary-care surgical units to better identify the best management as determined by short-term outcomes. Methods: We performed a retrospective review of patients who underwent surgery for insulinomas over a 117-month period at UT Southwestern Medical Center in Dallas (UTSW) and Queen Mary Hospital in Hong Kong (QMHK). Data collected included imaging studies, operative procedure, complications, and outcomes. Results: Thirty-seven patients were identified. Preoperative localization by computed tomography (CT) scan was successful in 21 patients (63.9%). In Hong Kong, 16 patients underwent selective arterial cannulation and calcium stimulation (SACST) with a success rate of 87.5%. Surgical management consisted of enucleation in 24 patients and distal pancreatectomy in 13 patients. Thirty patients underwent a concurrent intraoperative ultrasound, with localization in 96.7%. Laparoscopic procedures were accomplished in 20 patients. Nine postoperative complications were identified, four occurring in the laparoscopic group. Patients undergoing laparoscopic procedures had a decreased length-of-stay (LOS) compared with patients undergoing an open procedure and patients who had uncomplicated surgery had a trend toward decreased LOS. Conclusion: Though the accuracy of CT scans for localizing insulinomas is only 64%, the addition of SACST or intraoperative ultrasound and pancreatic palpation increases accuracy to 97.1%. Compared with open procedures, laparoscopic resection is associated with comparable complication rates and shorter hospital length of stay.

Original languageEnglish (US)
Pages (from-to)3532-3537
Number of pages6
JournalAnnals of Surgical Oncology
Volume15
Issue number12
DOIs
StatePublished - Dec 2008

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Insulinoma
Length of Stay
Hong Kong
Catheterization
Tomography
Calcium
Pancreatectomy
Minimally Invasive Surgical Procedures
Palpation
Operative Surgical Procedures
Tertiary Healthcare

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Surgical approach and perioperative complications determine short-term outcomes in patients with insulinoma : Results of a bi-institutional study. / Roland, Christina L.; Lo, Chung Yau; Miller, Barbra S.; Holt, Shelby; Nwariaku, Fiemu E.

In: Annals of Surgical Oncology, Vol. 15, No. 12, 12.2008, p. 3532-3537.

Research output: Contribution to journalArticle

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abstract = "Background: Despite advancements in radiologic imaging and minimally invasive surgery, the evaluation and management of insulinomas is institution and surgeon dependent. Therefore, the reported surgical outcomes are highly variable. We compared the surgical management and outcomes of insulinomas between two international tertiary-care surgical units to better identify the best management as determined by short-term outcomes. Methods: We performed a retrospective review of patients who underwent surgery for insulinomas over a 117-month period at UT Southwestern Medical Center in Dallas (UTSW) and Queen Mary Hospital in Hong Kong (QMHK). Data collected included imaging studies, operative procedure, complications, and outcomes. Results: Thirty-seven patients were identified. Preoperative localization by computed tomography (CT) scan was successful in 21 patients (63.9{\%}). In Hong Kong, 16 patients underwent selective arterial cannulation and calcium stimulation (SACST) with a success rate of 87.5{\%}. Surgical management consisted of enucleation in 24 patients and distal pancreatectomy in 13 patients. Thirty patients underwent a concurrent intraoperative ultrasound, with localization in 96.7{\%}. Laparoscopic procedures were accomplished in 20 patients. Nine postoperative complications were identified, four occurring in the laparoscopic group. Patients undergoing laparoscopic procedures had a decreased length-of-stay (LOS) compared with patients undergoing an open procedure and patients who had uncomplicated surgery had a trend toward decreased LOS. Conclusion: Though the accuracy of CT scans for localizing insulinomas is only 64{\%}, the addition of SACST or intraoperative ultrasound and pancreatic palpation increases accuracy to 97.1{\%}. Compared with open procedures, laparoscopic resection is associated with comparable complication rates and shorter hospital length of stay.",
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