Surgical-pathological findings in type 1 and 2 endometrial cancer

An NRG Oncology/Gynecologic Oncology Group study on GOG-210 protocol

William T. Creasman, Shamshad Ali, David G. Mutch, Richard J. Zaino, Matthew A. Powell, Robert S. Mannel, Floor J. Backes, Paul A. DiSilvestro, Peter A. Argenta, Michael L. Pearl, Shashikant B. Lele, Saketh R. Guntupalli, Steven Waggoner, Nick Spirtos, John F. Boggess, Robert P. Edwards, Virginia L. Filiaci, David S. Miller

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To report clinical and pathologic relationships with disease spread in endometrial cancer patients. Methods: Surgical candidates with uterine cancer (adenocarcinoma or carcinosarcoma) who were eligible to participate in a surgical pathological study to create a clinically annotated tissue biorepository to support translational and clinical research studies. All patients were to undergo a hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic and para-aortic lymphadenectomy. From 2003-2007, open eligibility enrollment was conducted, and from 2007-2011, eligibility was restricted to enrich underrepresented patients or those at high risk. Results: This report details clinical pathological relationships associated with extra uterine disease spread of 5866 evaluable patients including those with endometrioid histology as well as papillary serous, clear cell and carcinosarcoma histologies. Review of unrestricted enrollment was constructed in an effort to capture a cross-section population representative of endometrial cancers seen by the GOG participating members. Evaluation of this group of patients suggested the more natural incidence of different surgical pathological findings as well as demographic information. The addition of 2151 patients enrolled during the restricted time interval allowed a total of 1630 poor histotype patients available for further analysis. As expected, endometrioid (E) cancers represented the largest enrollment and particularly E grade 1 and 2 (G1 and 2) were more frequently confined to the uterus. Grade 3 (G3) endometrioid cancers as well as the poor histotype (papillary serous, clear cell and carcinosarcoma) had a much greater propensity for extant disease. Conclusions: This study confirms the previously reported surgical pathological findings for endometrioid cancers but in addition, using a large database of papillary serous, clear cell and carcinosarcoma, surgical pathological findings substantiate the categorization of poor histotypes for these cancers.

Original languageEnglish (US)
JournalGynecologic Oncology
DOIs
StateAccepted/In press - Feb 14 2017

Fingerprint

Endometrial Neoplasms
Carcinosarcoma
Neoplasms
Histology
Uterine Diseases
Uterine Neoplasms
Translational Medical Research
Ovariectomy
Lymph Node Excision
Hysterectomy
Uterus
Adenocarcinoma
Demography
Databases
Incidence
Population

Keywords

  • Poor histotypes
  • Surgical-pathology

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Surgical-pathological findings in type 1 and 2 endometrial cancer : An NRG Oncology/Gynecologic Oncology Group study on GOG-210 protocol. / Creasman, William T.; Ali, Shamshad; Mutch, David G.; Zaino, Richard J.; Powell, Matthew A.; Mannel, Robert S.; Backes, Floor J.; DiSilvestro, Paul A.; Argenta, Peter A.; Pearl, Michael L.; Lele, Shashikant B.; Guntupalli, Saketh R.; Waggoner, Steven; Spirtos, Nick; Boggess, John F.; Edwards, Robert P.; Filiaci, Virginia L.; Miller, David S.

In: Gynecologic Oncology, 14.02.2017.

Research output: Contribution to journalArticle

Creasman, WT, Ali, S, Mutch, DG, Zaino, RJ, Powell, MA, Mannel, RS, Backes, FJ, DiSilvestro, PA, Argenta, PA, Pearl, ML, Lele, SB, Guntupalli, SR, Waggoner, S, Spirtos, N, Boggess, JF, Edwards, RP, Filiaci, VL & Miller, DS 2017, 'Surgical-pathological findings in type 1 and 2 endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study on GOG-210 protocol', Gynecologic Oncology. https://doi.org/10.1016/j.ygyno.2017.03.017
Creasman, William T. ; Ali, Shamshad ; Mutch, David G. ; Zaino, Richard J. ; Powell, Matthew A. ; Mannel, Robert S. ; Backes, Floor J. ; DiSilvestro, Paul A. ; Argenta, Peter A. ; Pearl, Michael L. ; Lele, Shashikant B. ; Guntupalli, Saketh R. ; Waggoner, Steven ; Spirtos, Nick ; Boggess, John F. ; Edwards, Robert P. ; Filiaci, Virginia L. ; Miller, David S. / Surgical-pathological findings in type 1 and 2 endometrial cancer : An NRG Oncology/Gynecologic Oncology Group study on GOG-210 protocol. In: Gynecologic Oncology. 2017.
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AU - Mutch, David G.

AU - Zaino, Richard J.

AU - Powell, Matthew A.

AU - Mannel, Robert S.

AU - Backes, Floor J.

AU - DiSilvestro, Paul A.

AU - Argenta, Peter A.

AU - Pearl, Michael L.

AU - Lele, Shashikant B.

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AU - Waggoner, Steven

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AU - Edwards, Robert P.

AU - Filiaci, Virginia L.

AU - Miller, David S.

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N2 - Objective: To report clinical and pathologic relationships with disease spread in endometrial cancer patients. Methods: Surgical candidates with uterine cancer (adenocarcinoma or carcinosarcoma) who were eligible to participate in a surgical pathological study to create a clinically annotated tissue biorepository to support translational and clinical research studies. All patients were to undergo a hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic and para-aortic lymphadenectomy. From 2003-2007, open eligibility enrollment was conducted, and from 2007-2011, eligibility was restricted to enrich underrepresented patients or those at high risk. Results: This report details clinical pathological relationships associated with extra uterine disease spread of 5866 evaluable patients including those with endometrioid histology as well as papillary serous, clear cell and carcinosarcoma histologies. Review of unrestricted enrollment was constructed in an effort to capture a cross-section population representative of endometrial cancers seen by the GOG participating members. Evaluation of this group of patients suggested the more natural incidence of different surgical pathological findings as well as demographic information. The addition of 2151 patients enrolled during the restricted time interval allowed a total of 1630 poor histotype patients available for further analysis. As expected, endometrioid (E) cancers represented the largest enrollment and particularly E grade 1 and 2 (G1 and 2) were more frequently confined to the uterus. Grade 3 (G3) endometrioid cancers as well as the poor histotype (papillary serous, clear cell and carcinosarcoma) had a much greater propensity for extant disease. Conclusions: This study confirms the previously reported surgical pathological findings for endometrioid cancers but in addition, using a large database of papillary serous, clear cell and carcinosarcoma, surgical pathological findings substantiate the categorization of poor histotypes for these cancers.

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