Surrogate modeling of articular cartilage degradation to understand the synergistic role of MMP-1 and MMP-9: a case study

Mathematics

• Cartilage 83%
• Degradation 64%
• Surrogate 63%
• Extracellular Matrix 34%
• Modeling 34%
• Computational Model 26%
• Tensile Test 12%
• Protease 12%
• Collagen 11%
• Molecular Dynamics Simulation 11%
• Surrogate Model 11%
• Latin Hypercube Sampling 11%
• Multiscale Model 10%
• Indentation 10%
• Integrity 9%
• Spatial Distribution 9%
• Enzymes 9%
• Elasto-plastic 8%
• Damage 8%
• Mechanics 7%
• Model 2%

Medicine & Life Sciences

• Matrix Metalloproteinase 1 64%
• Matrix Metalloproteinase 9 56%
• Articular Cartilage 56%
• Gels 43%
• Cartilage 36%
• Gelatinases 28%
• Extracellular Matrix 26%
• Matrix Metalloproteinases 20%
• Cartilage Diseases 15%
• Microfibrils 15%
• Molecular Dynamics Simulation 11%
• Collagenases 11%
• Mechanics 10%
• Arthritis 9%
• Peptide Hydrolases 8%
• Collagen 7%
• Enzymes 5%

Engineering & Materials Science

• Metalloproteases 100%
• Cartilage 68%
• Gels 39%
• Degradation 36%
• Tissue 25%
• Peptide Hydrolases 11%
• Collagen 9%
• Enzymes 8%
• Molecular dynamics 8%
• Spatial distribution 8%
• Indentation 8%
• Mechanics 6%
• Sampling 5%
• Computer simulation 4%