TY - JOUR
T1 - Survival after delivery room cardiopulmonary resuscitation
T2 - A national registry study
AU - for the American Heart Association's Get With The Guidelines-Resuscitation Investigators
AU - Foglia, Elizabeth E.
AU - Jensen, Erik A.
AU - Wyckoff, Myra H.
AU - Sawyer, Taylor
AU - Topjian, Alexis
AU - Ratcliffe, Sarah J.
N1 - Funding Information:
Dr. Foglia is supported by a grant from the NICHD, K23HD084727. Dr. Jensen is supported by a grant from the NHLBI, K23HL136843. These funding sources had no role in the study design; data collection, analysis or interpretation; manuscript writing; or the decision to submit the manuscript for publication. IQVIA (Parsippany, New Jersey) served as the registry coordinating center. The University of Pennsylvania served as the data analytic center and granted the opportunity to prepare the data for research purposes. In addition to the authors Elizabeth E. Foglia MD MSCE and Taylor Sawyer DO MEd, members of the American Heart Association Get With the Guidelines- Resuscitation Pediatric Taskforce include Anne-Marie Guerguerian MD PhD FRCPC; Dianne Atkins MD; Ericka Fink MD; Javier J. Lasa MD FAAP; Joan Roberts MD; Jordan Duval-Arnould MPH DrPH; Melania M. Bembea MD MPH PhD; Michael Gaies MD MPH MSc; Monica Kleinman MD; Punkaj Gupta MBBS; Robert M. Sutton MD MSCE FAAP FCCM.
Funding Information:
Dr. Foglia is supported by a grant from the NICHD , K23HD084727 . Dr. Jensen is supported by a grant from the NHLBI , K23HL136843 . These funding sources had no role in the study design; data collection, analysis or interpretation; manuscript writing; or the decision to submit the manuscript for publication. IQVIA (Parsippany, New Jersey) served as the registry coordinating center. The University of Pennsylvania served as the data analytic center and granted the opportunity to prepare the data for research purposes.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/7
Y1 - 2020/7
N2 - Aims: Survival after delivery room cardiopulmonary resuscitation (DR-CPR) is not well characterized in full-term infants, and survival outcomes after DR-CPR have not been defined across the spectrum of gestation. The study objectives were to define gestational age (GA) specific survival following DR-CPR and to assess the association between GA and DR-CPR characteristics and survival outcomes. Methods: Retrospective cohort study of prospectively collected data in the American Heart Association Get With the Guidelines-Resuscitation registry. Newborn infants without congenital abnormalities who received greater than 1 min of chest compressions for DR-CPR were included. GA was stratified by categorical subgroups: ≥36 weeks; 33–356/7 weeks; 29–326/7 weeks; 25–286/7 weeks; 22–246/7 weeks. The primary outcome was survival to hospital discharge; the secondary outcome was return of circulation (ROC). Results: Among 1022 infants who received DR-CPR, 83% experienced ROC and 64% survived to hospital discharge. GA-stratified hospital survival rates were 83% (≥36 weeks), 66% (33–35 weeks), 60% (29–32 weeks), 52% (25–28 weeks), and 25% (22–24 weeks). Compared with GA ≥ 36 weeks, lower GA was independently associated with decreasing odds of survival (33–35 weeks: adjusted Odds Ratio [aOR] 0.46, 95% Confidence Interval [CI] 0.26–0.81; 29–32 weeks: aOR 0.40, 95% CI 0.23–0.69; 25–28 weeks: aOR 0.21, 95% CI 0.11–0.41; 22–24 weeks: aOR 0.06, 95% CI 0.03–0.10). Conclusions: In this national registry of infants who received delivery room cardiopulmonary resuscitation (DR-CPR), 83% survived the event and two-thirds survived to hospital discharge. These results contribute to defining survival outcomes following DR-CPR across the continuum of gestation.
AB - Aims: Survival after delivery room cardiopulmonary resuscitation (DR-CPR) is not well characterized in full-term infants, and survival outcomes after DR-CPR have not been defined across the spectrum of gestation. The study objectives were to define gestational age (GA) specific survival following DR-CPR and to assess the association between GA and DR-CPR characteristics and survival outcomes. Methods: Retrospective cohort study of prospectively collected data in the American Heart Association Get With the Guidelines-Resuscitation registry. Newborn infants without congenital abnormalities who received greater than 1 min of chest compressions for DR-CPR were included. GA was stratified by categorical subgroups: ≥36 weeks; 33–356/7 weeks; 29–326/7 weeks; 25–286/7 weeks; 22–246/7 weeks. The primary outcome was survival to hospital discharge; the secondary outcome was return of circulation (ROC). Results: Among 1022 infants who received DR-CPR, 83% experienced ROC and 64% survived to hospital discharge. GA-stratified hospital survival rates were 83% (≥36 weeks), 66% (33–35 weeks), 60% (29–32 weeks), 52% (25–28 weeks), and 25% (22–24 weeks). Compared with GA ≥ 36 weeks, lower GA was independently associated with decreasing odds of survival (33–35 weeks: adjusted Odds Ratio [aOR] 0.46, 95% Confidence Interval [CI] 0.26–0.81; 29–32 weeks: aOR 0.40, 95% CI 0.23–0.69; 25–28 weeks: aOR 0.21, 95% CI 0.11–0.41; 22–24 weeks: aOR 0.06, 95% CI 0.03–0.10). Conclusions: In this national registry of infants who received delivery room cardiopulmonary resuscitation (DR-CPR), 83% survived the event and two-thirds survived to hospital discharge. These results contribute to defining survival outcomes following DR-CPR across the continuum of gestation.
KW - Cardiopulmonary resuscitation
KW - Delivery room
KW - Newborn
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85078854432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078854432&partnerID=8YFLogxK
U2 - 10.1016/j.resuscitation.2020.01.010
DO - 10.1016/j.resuscitation.2020.01.010
M3 - Article
C2 - 31982507
AN - SCOPUS:85078854432
SN - 0300-9572
VL - 152
SP - 177
EP - 183
JO - Resuscitation
JF - Resuscitation
ER -