Survival in small cell lung cancer is independent of tumor expression of VEGF and COX-2

Jonathan E. Dowell, Robin H. Amirkhan, Wen S. Lai, William H. Frawley, John D. Minna

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background: Preclinical data suggests that VEGF and COX-2 are potentially important mediators in the pathogenesis of small cell lung cancer (SCLC). Little is known about the frequency of tumor expression of VEGF and COX-2 in SCLC or the prognostic significance of this expression. Materials and Methods: Clinical records from 54 cases of SCLC were reviewed. Immunohistochemical stains for VEGF and COX-2 were performed on all tumor specimens. Results: Tumor VEGF expression was detected in 43 cases (81%) and COX-2 expression in 11 (20%). No significant association between VEGF or COX-2 expression and survival was observed. Conclusion: This is the first study to assess the frequency and clinical significance of tumor VEGF and COX-2 expression in a large group of patients with SCLC. In this cohort, neither VEGF nor COX-2 expression impacted survival. The frequency of VEGF expression suggests that it merits further investigation as a therapeutic target in SCLC.

Original languageEnglish (US)
Pages (from-to)2367-2373
Number of pages7
JournalAnticancer Research
Issue number4
StatePublished - Jul 2004


  • Angiogenesis
  • Lung neoplasms
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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