Abstract
Background: Preclinical data suggests that VEGF and COX-2 are potentially important mediators in the pathogenesis of small cell lung cancer (SCLC). Little is known about the frequency of tumor expression of VEGF and COX-2 in SCLC or the prognostic significance of this expression. Materials and Methods: Clinical records from 54 cases of SCLC were reviewed. Immunohistochemical stains for VEGF and COX-2 were performed on all tumor specimens. Results: Tumor VEGF expression was detected in 43 cases (81%) and COX-2 expression in 11 (20%). No significant association between VEGF or COX-2 expression and survival was observed. Conclusion: This is the first study to assess the frequency and clinical significance of tumor VEGF and COX-2 expression in a large group of patients with SCLC. In this cohort, neither VEGF nor COX-2 expression impacted survival. The frequency of VEGF expression suggests that it merits further investigation as a therapeutic target in SCLC.
Original language | English (US) |
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Pages (from-to) | 2367-2373 |
Number of pages | 7 |
Journal | Anticancer Research |
Volume | 24 |
Issue number | 4 |
State | Published - Jul 2004 |
Keywords
- Angiogenesis
- Lung neoplasms
- Prognosis
ASJC Scopus subject areas
- Oncology
- Cancer Research