@article{519d51dc7080483fb8946c894bb04282,
title = "Survival outcome following isolated central nervous system relapse treated with additional chemotherapy and craniospinal irradiation in childhood acute lymphoblastic leukemia",
keywords = "Acute lymphoblastic leukemia, Chemotherapy intensification, Craniospinal irradiation, Isolated central nervous system relapse",
author = "Parvesh Kumar and Kun, {Larry E.} and Hustu, {H. Omar} and Mulhern, {Raymond K.} and Hancock, {Michael L.} and Douglas Coffey and Rivera, {Gaston K.}",
note = "Funding Information: Despite modern era “preventive” central nervous system (CNS) therapy, approximately 5-10% of children with acute lymphoblastic leukemia (ALL) evidence an isolated meningeal relapse during initial hematologic remission (3, 6, 9. 12). The prognosis for this subset of patients re- Supportedin part by Cancer Center Support CORE Grant, P30 CA 21765 and the American LebaneseS yrian Associated Charities( ALSAC). Reprint requestst o: ParveshK umar. M.D., Department of Radiation Oncology, St. JudeC hildren{\textquoteright}sR esearchH ospital.3 32 N. Lauderdale,M emphis, TN, 38 105. Acknowledgements-Thisw ork wass upportedin part by Cancer mains poor. Children treated for meningeal leukemia are at increased risk for subsequentC NS and/or bone marrow relapse. Importantly, those who survive appear to experience significant neuropsychological sequelae ( 1, 7, 8). Durable control of overt meningeal relapse is pivotal for limiting further neurotoxicity and mortality.",
year = "1995",
month = feb,
day = "1",
doi = "10.1016/0360-3016(94)00344-K",
language = "English (US)",
volume = "31",
pages = "477--483",
journal = "International journal of radiation oncology, biology, physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "3",
}