TY - JOUR
T1 - Survivin
T2 - A promising biomarker for detection and prognosis of bladder cancer
AU - Margulis, Vitaly
AU - Lotan, Yair
AU - Shariat, Shahrokh F.
PY - 2008/2
Y1 - 2008/2
N2 - Survivin is a 16.5 kDa member of the inhibitor of apoptosis protein family that is overexpressed in many malignancies but rarely detected in normal differentiated adult tissues. Functionally, Survivin inhibits apoptosis, promotes cell proliferation, and induces/enhances angiogenesis. In transitional cell carcinoma of the urinary bladder, Survivin has been shown to be a promising biomarker for cancer diagnosis, prognosis and prediction of response to intravesical or systemic therapies. Moreover, in pre-clinical bladder tumor models, inhibition of Survivin expression and/or function has been shown to impede tumor cell proliferation, and markedly induce spontaneous or chemotherapy induced apoptosis. These preliminary findings should now be confirmed in large prospective trials. Furthermore, simplified, quantitative and reproducible assays need to be developed and validated for the detection of Survivin and its different isoforms.
AB - Survivin is a 16.5 kDa member of the inhibitor of apoptosis protein family that is overexpressed in many malignancies but rarely detected in normal differentiated adult tissues. Functionally, Survivin inhibits apoptosis, promotes cell proliferation, and induces/enhances angiogenesis. In transitional cell carcinoma of the urinary bladder, Survivin has been shown to be a promising biomarker for cancer diagnosis, prognosis and prediction of response to intravesical or systemic therapies. Moreover, in pre-clinical bladder tumor models, inhibition of Survivin expression and/or function has been shown to impede tumor cell proliferation, and markedly induce spontaneous or chemotherapy induced apoptosis. These preliminary findings should now be confirmed in large prospective trials. Furthermore, simplified, quantitative and reproducible assays need to be developed and validated for the detection of Survivin and its different isoforms.
KW - Bladder cancer
KW - Detection
KW - Prognosis
KW - Survivin
KW - Target
KW - Urine
UR - http://www.scopus.com/inward/record.url?scp=39349098773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39349098773&partnerID=8YFLogxK
U2 - 10.1007/s00345-007-0219-y
DO - 10.1007/s00345-007-0219-y
M3 - Article
C2 - 17962949
AN - SCOPUS:39349098773
SN - 0724-4983
VL - 26
SP - 59
EP - 65
JO - World journal of urology
JF - World journal of urology
IS - 1
ER -