Survivin expression is associated with bladder cancer presence, stage, progression, and mortality

Shahrokh F. Shariat, Raheela Ashfaq, Pierre I. Karakiewicz, Osamah Saeedi, Arthur I Sagalowsky, Yair Lotan

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

BACKGROUND. The purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes. METHODS. Immunohistochemical staining for Survivin was carried out on archival bladder specimens from 9 normal controls and 222 consecutive patients who underwent radical cystectomy and bilateral lymphadenectomy. Lymph node tissue involved with TCC from 50 of the 222 cystectomy patients was also evaluated. RESULTS. Survivin was expressed in none of the normal bladder specimens, 64% of the cystectomy specimens, and 94% of the malignant lymph nodes. Multivariable analyses performed in the cystectomy patients revealed that Survivin expression was associated with disease recurrence (P = .040), disease-specific mortality (P = .037), and all-cause mortality (P = .044). CONCLUSIONS. The findings of the study provide a rationale for further evaluation of Survivin and its downstream signaling pathways in bladder cancer and raise the potential for Survivin-targeted therapy for bladder cancer.

Original languageEnglish (US)
Pages (from-to)1106-1113
Number of pages8
JournalCancer
Volume109
Issue number6
DOIs
StatePublished - Mar 15 2007

Keywords

  • Death
  • Immunohistochemistry
  • Progression
  • Survivin
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Survivin expression is associated with bladder cancer presence, stage, progression, and mortality'. Together they form a unique fingerprint.

  • Cite this