Survivin is not an independent prognostic factor for patients with upper tract urothelial carcinoma: A multi-institutional study

Romain Mathieu, Tobias Klatte, Vitaly Margulis, Jose A. Karam, Morgan Rouprêt, Christian Seitz, Pierre I. Karakiewicz, Harun Fajkovic, Christopher G. Wood, Alon Z. Weizer, Jay D. Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Karim Bensalah, Yair Lotan, Michael Rink, Luis A. Kluth, Douglas S. Scherr, Brian D. RobinsonShahrokh F. Shariat

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Several small single-center studies have reported conflicting results on the prognostic value of survivin expression in upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy. We attempted to validate the prognostic utility of survivin using a large multi-institutional cohort. Material and methods: Survivin expression was evaluated by immunohistochemistry in tumor tissue from 732 patients with unilateral, sporadic UTUC treated with radical nephroureterectomy between 1990 and 2008 at 7 centers. Survivin expression was considered altered when at least 10% of the tumor cells stained positive. Associations of altered survivin expression with recurrence-free survival (RFS) and cancer-specific survival (CSS) were evaluated using Cox proportional hazards regression models. Results: Altered survivin expression was observed in 288 (39.3%) tumors and was associated with more advanced pathological tumor stages ( P

Original languageEnglish (US)
Pages (from-to)495.e15-495.e22
JournalUrologic Oncology: Seminars and Original Investigations
Volume33
Issue number11
DOIs
StatePublished - Nov 1 2015

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Carcinoma
Neoplasms
Survival
Proportional Hazards Models
Immunohistochemistry
Recurrence

Keywords

  • Carcinoma
  • Death
  • Recurrence
  • Survivin
  • Urothelium

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Survivin is not an independent prognostic factor for patients with upper tract urothelial carcinoma : A multi-institutional study. / Mathieu, Romain; Klatte, Tobias; Margulis, Vitaly; Karam, Jose A.; Rouprêt, Morgan; Seitz, Christian; Karakiewicz, Pierre I.; Fajkovic, Harun; Wood, Christopher G.; Weizer, Alon Z.; Raman, Jay D.; Remzi, Mesut; Rioux-Leclercq, Nathalie; Haitel, Andrea; Bensalah, Karim; Lotan, Yair; Rink, Michael; Kluth, Luis A.; Scherr, Douglas S.; Robinson, Brian D.; Shariat, Shahrokh F.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 33, No. 11, 01.11.2015, p. 495.e15-495.e22.

Research output: Contribution to journalArticle

Mathieu, R, Klatte, T, Margulis, V, Karam, JA, Rouprêt, M, Seitz, C, Karakiewicz, PI, Fajkovic, H, Wood, CG, Weizer, AZ, Raman, JD, Remzi, M, Rioux-Leclercq, N, Haitel, A, Bensalah, K, Lotan, Y, Rink, M, Kluth, LA, Scherr, DS, Robinson, BD & Shariat, SF 2015, 'Survivin is not an independent prognostic factor for patients with upper tract urothelial carcinoma: A multi-institutional study', Urologic Oncology: Seminars and Original Investigations, vol. 33, no. 11, pp. 495.e15-495.e22. https://doi.org/10.1016/j.urolonc.2015.06.016
Mathieu, Romain ; Klatte, Tobias ; Margulis, Vitaly ; Karam, Jose A. ; Rouprêt, Morgan ; Seitz, Christian ; Karakiewicz, Pierre I. ; Fajkovic, Harun ; Wood, Christopher G. ; Weizer, Alon Z. ; Raman, Jay D. ; Remzi, Mesut ; Rioux-Leclercq, Nathalie ; Haitel, Andrea ; Bensalah, Karim ; Lotan, Yair ; Rink, Michael ; Kluth, Luis A. ; Scherr, Douglas S. ; Robinson, Brian D. ; Shariat, Shahrokh F. / Survivin is not an independent prognostic factor for patients with upper tract urothelial carcinoma : A multi-institutional study. In: Urologic Oncology: Seminars and Original Investigations. 2015 ; Vol. 33, No. 11. pp. 495.e15-495.e22.
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T1 - Survivin is not an independent prognostic factor for patients with upper tract urothelial carcinoma

T2 - A multi-institutional study

AU - Mathieu, Romain

AU - Klatte, Tobias

AU - Margulis, Vitaly

AU - Karam, Jose A.

AU - Rouprêt, Morgan

AU - Seitz, Christian

AU - Karakiewicz, Pierre I.

AU - Fajkovic, Harun

AU - Wood, Christopher G.

AU - Weizer, Alon Z.

AU - Raman, Jay D.

AU - Remzi, Mesut

AU - Rioux-Leclercq, Nathalie

AU - Haitel, Andrea

AU - Bensalah, Karim

AU - Lotan, Yair

AU - Rink, Michael

AU - Kluth, Luis A.

AU - Scherr, Douglas S.

AU - Robinson, Brian D.

AU - Shariat, Shahrokh F.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Objective: Several small single-center studies have reported conflicting results on the prognostic value of survivin expression in upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy. We attempted to validate the prognostic utility of survivin using a large multi-institutional cohort. Material and methods: Survivin expression was evaluated by immunohistochemistry in tumor tissue from 732 patients with unilateral, sporadic UTUC treated with radical nephroureterectomy between 1990 and 2008 at 7 centers. Survivin expression was considered altered when at least 10% of the tumor cells stained positive. Associations of altered survivin expression with recurrence-free survival (RFS) and cancer-specific survival (CSS) were evaluated using Cox proportional hazards regression models. Results: Altered survivin expression was observed in 288 (39.3%) tumors and was associated with more advanced pathological tumor stages ( P

AB - Objective: Several small single-center studies have reported conflicting results on the prognostic value of survivin expression in upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy. We attempted to validate the prognostic utility of survivin using a large multi-institutional cohort. Material and methods: Survivin expression was evaluated by immunohistochemistry in tumor tissue from 732 patients with unilateral, sporadic UTUC treated with radical nephroureterectomy between 1990 and 2008 at 7 centers. Survivin expression was considered altered when at least 10% of the tumor cells stained positive. Associations of altered survivin expression with recurrence-free survival (RFS) and cancer-specific survival (CSS) were evaluated using Cox proportional hazards regression models. Results: Altered survivin expression was observed in 288 (39.3%) tumors and was associated with more advanced pathological tumor stages ( P

KW - Carcinoma

KW - Death

KW - Recurrence

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