Susceptibility of corneal and conjunctival pathogens to ciprofloxacin

Herbert P. Knauf, Robert Silvany, Paul M. Southern, Rick C. Risser, Steven E. Wilson

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Ciprofloxacin 0.3% ophthalmic solution has been shown to be effective in the treatment of bacterial keratitis and conjunctivitis, and many physicians use ciprofloxacin as sole therapy in these conditions. In this retrospective study, we found seven of 84 isolates from corneal and conjunctival cultures that were resistant to ciprofloxacin. All of the resistant organisms were gram positive. Six of the isolates (Staphylococcus aureus, Staphylococcus hominis, and four isolates of the Streptococcus viridans group) were from corneal cultures, and one Staphylococcus aureus) from a conjunctival culture. Yearly records of systemic isolates from 1988 to 1993 (n = 35,308) demonstrated a statistically significant decrease in susceptibility for several organisms that are common pathogens in the conjunctiva and cornea: Pseudomonas aeruginosa (95-90%, p = 0.001); Staphylococcus aureus (96-87%, p < 0.0001); Staphylococcus spp., coagulase negative (97-81%, p < 0.0001); Enterococcus spp. (9279%, p < 0.0001); Acinetobacter anitratus (97-77%, p = 0.0006);, and Enterobacter cloacae (100-96%, p = 0.03). Although the susceptibility of corneal and conjunctival isolates in this series remained relatively high (91.7%), a much larger series of systemic isolates that are common ocular pathogens revealed a statistically significant increase in resistance to ciprofloxacin over the preceding 5 years.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalCornea
Volume15
Issue number1
StatePublished - 1996

Fingerprint

Ciprofloxacin
Staphylococcus aureus
Staphylococcus hominis
Bacterial Conjunctivitis
Viridans Streptococci
Enterobacter cloacae
Acinetobacter
Keratitis
Ophthalmic Solutions
Coagulase
Conjunctiva
Enterococcus
Staphylococcus
Cornea
Pseudomonas aeruginosa
Retrospective Studies
Physicians
Therapeutics

Keywords

  • Ciprofloxacin
  • Cornea
  • Infection
  • Keratis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Knauf, H. P., Silvany, R., Southern, P. M., Risser, R. C., & Wilson, S. E. (1996). Susceptibility of corneal and conjunctival pathogens to ciprofloxacin. Cornea, 15(1), 66-71.

Susceptibility of corneal and conjunctival pathogens to ciprofloxacin. / Knauf, Herbert P.; Silvany, Robert; Southern, Paul M.; Risser, Rick C.; Wilson, Steven E.

In: Cornea, Vol. 15, No. 1, 1996, p. 66-71.

Research output: Contribution to journalArticle

Knauf, HP, Silvany, R, Southern, PM, Risser, RC & Wilson, SE 1996, 'Susceptibility of corneal and conjunctival pathogens to ciprofloxacin', Cornea, vol. 15, no. 1, pp. 66-71.
Knauf HP, Silvany R, Southern PM, Risser RC, Wilson SE. Susceptibility of corneal and conjunctival pathogens to ciprofloxacin. Cornea. 1996;15(1):66-71.
Knauf, Herbert P. ; Silvany, Robert ; Southern, Paul M. ; Risser, Rick C. ; Wilson, Steven E. / Susceptibility of corneal and conjunctival pathogens to ciprofloxacin. In: Cornea. 1996 ; Vol. 15, No. 1. pp. 66-71.
@article{c815c352f0df443fa3605d79a2fd251c,
title = "Susceptibility of corneal and conjunctival pathogens to ciprofloxacin",
abstract = "Ciprofloxacin 0.3{\%} ophthalmic solution has been shown to be effective in the treatment of bacterial keratitis and conjunctivitis, and many physicians use ciprofloxacin as sole therapy in these conditions. In this retrospective study, we found seven of 84 isolates from corneal and conjunctival cultures that were resistant to ciprofloxacin. All of the resistant organisms were gram positive. Six of the isolates (Staphylococcus aureus, Staphylococcus hominis, and four isolates of the Streptococcus viridans group) were from corneal cultures, and one Staphylococcus aureus) from a conjunctival culture. Yearly records of systemic isolates from 1988 to 1993 (n = 35,308) demonstrated a statistically significant decrease in susceptibility for several organisms that are common pathogens in the conjunctiva and cornea: Pseudomonas aeruginosa (95-90{\%}, p = 0.001); Staphylococcus aureus (96-87{\%}, p < 0.0001); Staphylococcus spp., coagulase negative (97-81{\%}, p < 0.0001); Enterococcus spp. (9279{\%}, p < 0.0001); Acinetobacter anitratus (97-77{\%}, p = 0.0006);, and Enterobacter cloacae (100-96{\%}, p = 0.03). Although the susceptibility of corneal and conjunctival isolates in this series remained relatively high (91.7{\%}), a much larger series of systemic isolates that are common ocular pathogens revealed a statistically significant increase in resistance to ciprofloxacin over the preceding 5 years.",
keywords = "Ciprofloxacin, Cornea, Infection, Keratis",
author = "Knauf, {Herbert P.} and Robert Silvany and Southern, {Paul M.} and Risser, {Rick C.} and Wilson, {Steven E.}",
year = "1996",
language = "English (US)",
volume = "15",
pages = "66--71",
journal = "Cornea",
issn = "0277-3740",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Susceptibility of corneal and conjunctival pathogens to ciprofloxacin

AU - Knauf, Herbert P.

AU - Silvany, Robert

AU - Southern, Paul M.

AU - Risser, Rick C.

AU - Wilson, Steven E.

PY - 1996

Y1 - 1996

N2 - Ciprofloxacin 0.3% ophthalmic solution has been shown to be effective in the treatment of bacterial keratitis and conjunctivitis, and many physicians use ciprofloxacin as sole therapy in these conditions. In this retrospective study, we found seven of 84 isolates from corneal and conjunctival cultures that were resistant to ciprofloxacin. All of the resistant organisms were gram positive. Six of the isolates (Staphylococcus aureus, Staphylococcus hominis, and four isolates of the Streptococcus viridans group) were from corneal cultures, and one Staphylococcus aureus) from a conjunctival culture. Yearly records of systemic isolates from 1988 to 1993 (n = 35,308) demonstrated a statistically significant decrease in susceptibility for several organisms that are common pathogens in the conjunctiva and cornea: Pseudomonas aeruginosa (95-90%, p = 0.001); Staphylococcus aureus (96-87%, p < 0.0001); Staphylococcus spp., coagulase negative (97-81%, p < 0.0001); Enterococcus spp. (9279%, p < 0.0001); Acinetobacter anitratus (97-77%, p = 0.0006);, and Enterobacter cloacae (100-96%, p = 0.03). Although the susceptibility of corneal and conjunctival isolates in this series remained relatively high (91.7%), a much larger series of systemic isolates that are common ocular pathogens revealed a statistically significant increase in resistance to ciprofloxacin over the preceding 5 years.

AB - Ciprofloxacin 0.3% ophthalmic solution has been shown to be effective in the treatment of bacterial keratitis and conjunctivitis, and many physicians use ciprofloxacin as sole therapy in these conditions. In this retrospective study, we found seven of 84 isolates from corneal and conjunctival cultures that were resistant to ciprofloxacin. All of the resistant organisms were gram positive. Six of the isolates (Staphylococcus aureus, Staphylococcus hominis, and four isolates of the Streptococcus viridans group) were from corneal cultures, and one Staphylococcus aureus) from a conjunctival culture. Yearly records of systemic isolates from 1988 to 1993 (n = 35,308) demonstrated a statistically significant decrease in susceptibility for several organisms that are common pathogens in the conjunctiva and cornea: Pseudomonas aeruginosa (95-90%, p = 0.001); Staphylococcus aureus (96-87%, p < 0.0001); Staphylococcus spp., coagulase negative (97-81%, p < 0.0001); Enterococcus spp. (9279%, p < 0.0001); Acinetobacter anitratus (97-77%, p = 0.0006);, and Enterobacter cloacae (100-96%, p = 0.03). Although the susceptibility of corneal and conjunctival isolates in this series remained relatively high (91.7%), a much larger series of systemic isolates that are common ocular pathogens revealed a statistically significant increase in resistance to ciprofloxacin over the preceding 5 years.

KW - Ciprofloxacin

KW - Cornea

KW - Infection

KW - Keratis

UR - http://www.scopus.com/inward/record.url?scp=0030066982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030066982&partnerID=8YFLogxK

M3 - Article

C2 - 8907383

AN - SCOPUS:0030066982

VL - 15

SP - 66

EP - 71

JO - Cornea

JF - Cornea

SN - 0277-3740

IS - 1

ER -