Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor

S. M J Fleiszig, V. Vallas, C. H. Jun, L. Mok, D. F. Balkovetz, M. G. Roth, K. E. Mostov

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Normal cell polarity protects epithelial cells against Pseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered without disrupting tight junctions. The results also showed that cellular susceptibility factors for invasion and cytotoxicity are not the same, although both are localized to the basolateral cell surface in polarized epithelial cells.

Original languageEnglish (US)
Pages (from-to)3443-3446
Number of pages4
JournalInfection and immunity
Volume66
Issue number7
StatePublished - Jul 14 1998

    Fingerprint

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Fleiszig, S. M. J., Vallas, V., Jun, C. H., Mok, L., Balkovetz, D. F., Roth, M. G., & Mostov, K. E. (1998). Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor. Infection and immunity, 66(7), 3443-3446.