Abstract
What is Known and Objective: Opioids are commonly administered to infants having surgery. Opioid induced hyperalgesia (OIH) is a known adverse effect of opioids in adults but can be difficult to identify in infants. Case Summary: A 3-month-old received high-dose fentanyl during anorectoplasty for imperforate anus. He had signs and symptoms of OIH immediately after surgery. His pain and agitation were difficult to manage but improved after he received ketamine. What is New and Conclusion: OIH should be considered in infants postoperatively when pain worsens despite administration of escalating doses of opioids. Ketamine can be an effective therapeutic for OIH.
Original language | English (US) |
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Pages (from-to) | 1486-1489 |
Number of pages | 4 |
Journal | Journal of Clinical Pharmacy and Therapeutics |
Volume | 47 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2022 |
Keywords
- infants
- opioid
- pain
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)