Sustained impairments in cutaneous vasodilation and sweating in grafted skin following long-term recovery

Scott L. Davis, Manabu Shibasaki, David A. Low, Jian Cui, David M. Keller, Jonathan E. Wingo, Gary F. Purdue, John L. Hunt, Brett D. Arnoldo, Karen J. Kowalske, Craig G. Crandall

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22 Citations (Scopus)

Abstract

We previously identified impaired cutaneous vasodilation and sweating in grafted skin 5 to 9 months postsurgery. The aim of this investigation was to test the hypothesis that cutaneous vasodilation, but not sweating, is restored as the graft heals. Skin blood flow and sweat rate were assessed from grafted skin and adjacent noninjured skin in three groups of subjects: 5 to 9 months postsurgery (n = 13), 2 to 3 years postsurgery (n = 13), and 4 to 8 years postsurgery (n = 13) during three separate protocols: 1) whole-body heating and cooling, 2) local administration of vasoactive drugs, and 3) local heating and cooling. Cutaneous vasodilation and sweating during whole-body heating were significantly lower (P < .001) in grafted skin when compared with noninjured skin across all groups and demonstrated no improvements with recovery time postsurgery. Maximal endothelial-dependent (acetylcholine) and endothelial-independent (sodium nitroprusside) cutaneous vasodilation remained attenuated (P < .001) in grafted skin up to 4 to 8 years postsurgery, indicating postsynaptic impairments. In grafted skin, cutaneous vasoconstriction during whole-body and local cooling was preserved, whereas vasodilation to local heating was impaired, regardless of the duration postsurgery. Split-thickness skin grafts have impaired cutaneous vasodilation and sweating up to 4 to 8 years postsurgery, thereby limiting the capability of this skin's contribution to thermoregulation during a heats stress. In contrast, grafted skin has preserved vasoconstrictor capacity.

Original languageEnglish (US)
Pages (from-to)675-685
Number of pages11
JournalJournal of Burn Care and Research
Volume30
Issue number4
DOIs
StatePublished - Jul 2009

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Sweating
Vasodilation
Skin
Heating
Transplants
Sweat
Body Temperature Regulation
Nitroprusside
Vasoconstrictor Agents

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

Cite this

Sustained impairments in cutaneous vasodilation and sweating in grafted skin following long-term recovery. / Davis, Scott L.; Shibasaki, Manabu; Low, David A.; Cui, Jian; Keller, David M.; Wingo, Jonathan E.; Purdue, Gary F.; Hunt, John L.; Arnoldo, Brett D.; Kowalske, Karen J.; Crandall, Craig G.

In: Journal of Burn Care and Research, Vol. 30, No. 4, 07.2009, p. 675-685.

Research output: Contribution to journalArticle

Davis, Scott L. ; Shibasaki, Manabu ; Low, David A. ; Cui, Jian ; Keller, David M. ; Wingo, Jonathan E. ; Purdue, Gary F. ; Hunt, John L. ; Arnoldo, Brett D. ; Kowalske, Karen J. ; Crandall, Craig G. / Sustained impairments in cutaneous vasodilation and sweating in grafted skin following long-term recovery. In: Journal of Burn Care and Research. 2009 ; Vol. 30, No. 4. pp. 675-685.
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