Sustained increase in gastric antral epithelial cell proliferation despite cure of Helicobacter pylori infection

Hala M T El-Zimaity, David Y. Graham, Robert M. Genta, Juan Lechago

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVE: Studies of the effect of Helicobacter pylori treatment on gastric mucosa proliferation have yielded inconsistent results. We compared gastric mucosa cell proliferation posttherapy and in uninfected controls. METHODS: Biopsies were obtained from patients with H. pylori infection before treatment and at intervals for up to 33 months. Epithelial cell proliferation was determined using Ki-67 immunostaining. The labeling index (LI) is the proportion of positively labeled cells with respect to the total number of cells. The proliferative index was calculated by multiplying the labeling index (LI) and the proliferation zone PZ (PZ = length of the area between the uppermost and lowest labeled cells). RESULTS: The study included 27 patients with H. pylori gastritis and 35 controls. Epithelial cell proliferation (LI) was greater with H. pylori infection than without in both the antrum and corpus (65 ± 5 vs 91 ± 8 in the antrum and 44 ± 4 vs 72 ± 8 in the corpus, for uninfected controls vs H. pylori gastritis, respectively) (p = 0.0001). In the antrum there was no significant decrease in epithelial cell proliferation after cure of the H. pylori infection despite follow-up for >2 yr (labeling index = 83 ± 10). In contrast, epithelial cell proliferation decreased in the corpus and became similar to that in controls after 7-13 months. CONCLUSIONS: Patients with H. pylori infection have sustained high epithelial cell proliferation in the antrum compared to that in uninfected subjects. A continued increase in proliferation in the antrum after cure of H. pylori infection suggests continuing damage. (C) 2000 by Am. Coll. of Gastroenterology.

Original languageEnglish (US)
Pages (from-to)930-935
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume95
Issue number4
DOIs
StatePublished - Apr 2000

Fingerprint

Helicobacter Infections
Helicobacter pylori
Stomach
Epithelial Cells
Cell Proliferation
Gastritis
Gastric Mucosa
Antral
Gastroenterology
Cell Count
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sustained increase in gastric antral epithelial cell proliferation despite cure of Helicobacter pylori infection. / El-Zimaity, Hala M T; Graham, David Y.; Genta, Robert M.; Lechago, Juan.

In: American Journal of Gastroenterology, Vol. 95, No. 4, 04.2000, p. 930-935.

Research output: Contribution to journalArticle

El-Zimaity, Hala M T ; Graham, David Y. ; Genta, Robert M. ; Lechago, Juan. / Sustained increase in gastric antral epithelial cell proliferation despite cure of Helicobacter pylori infection. In: American Journal of Gastroenterology. 2000 ; Vol. 95, No. 4. pp. 930-935.
@article{b0ef11ec24084b4fbe65e7e09c672fd8,
title = "Sustained increase in gastric antral epithelial cell proliferation despite cure of Helicobacter pylori infection",
abstract = "OBJECTIVE: Studies of the effect of Helicobacter pylori treatment on gastric mucosa proliferation have yielded inconsistent results. We compared gastric mucosa cell proliferation posttherapy and in uninfected controls. METHODS: Biopsies were obtained from patients with H. pylori infection before treatment and at intervals for up to 33 months. Epithelial cell proliferation was determined using Ki-67 immunostaining. The labeling index (LI) is the proportion of positively labeled cells with respect to the total number of cells. The proliferative index was calculated by multiplying the labeling index (LI) and the proliferation zone PZ (PZ = length of the area between the uppermost and lowest labeled cells). RESULTS: The study included 27 patients with H. pylori gastritis and 35 controls. Epithelial cell proliferation (LI) was greater with H. pylori infection than without in both the antrum and corpus (65 ± 5 vs 91 ± 8 in the antrum and 44 ± 4 vs 72 ± 8 in the corpus, for uninfected controls vs H. pylori gastritis, respectively) (p = 0.0001). In the antrum there was no significant decrease in epithelial cell proliferation after cure of the H. pylori infection despite follow-up for >2 yr (labeling index = 83 ± 10). In contrast, epithelial cell proliferation decreased in the corpus and became similar to that in controls after 7-13 months. CONCLUSIONS: Patients with H. pylori infection have sustained high epithelial cell proliferation in the antrum compared to that in uninfected subjects. A continued increase in proliferation in the antrum after cure of H. pylori infection suggests continuing damage. (C) 2000 by Am. Coll. of Gastroenterology.",
author = "El-Zimaity, {Hala M T} and Graham, {David Y.} and Genta, {Robert M.} and Juan Lechago",
year = "2000",
month = "4",
doi = "10.1016/S0002-9270(00)00724-3",
language = "English (US)",
volume = "95",
pages = "930--935",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Sustained increase in gastric antral epithelial cell proliferation despite cure of Helicobacter pylori infection

AU - El-Zimaity, Hala M T

AU - Graham, David Y.

AU - Genta, Robert M.

AU - Lechago, Juan

PY - 2000/4

Y1 - 2000/4

N2 - OBJECTIVE: Studies of the effect of Helicobacter pylori treatment on gastric mucosa proliferation have yielded inconsistent results. We compared gastric mucosa cell proliferation posttherapy and in uninfected controls. METHODS: Biopsies were obtained from patients with H. pylori infection before treatment and at intervals for up to 33 months. Epithelial cell proliferation was determined using Ki-67 immunostaining. The labeling index (LI) is the proportion of positively labeled cells with respect to the total number of cells. The proliferative index was calculated by multiplying the labeling index (LI) and the proliferation zone PZ (PZ = length of the area between the uppermost and lowest labeled cells). RESULTS: The study included 27 patients with H. pylori gastritis and 35 controls. Epithelial cell proliferation (LI) was greater with H. pylori infection than without in both the antrum and corpus (65 ± 5 vs 91 ± 8 in the antrum and 44 ± 4 vs 72 ± 8 in the corpus, for uninfected controls vs H. pylori gastritis, respectively) (p = 0.0001). In the antrum there was no significant decrease in epithelial cell proliferation after cure of the H. pylori infection despite follow-up for >2 yr (labeling index = 83 ± 10). In contrast, epithelial cell proliferation decreased in the corpus and became similar to that in controls after 7-13 months. CONCLUSIONS: Patients with H. pylori infection have sustained high epithelial cell proliferation in the antrum compared to that in uninfected subjects. A continued increase in proliferation in the antrum after cure of H. pylori infection suggests continuing damage. (C) 2000 by Am. Coll. of Gastroenterology.

AB - OBJECTIVE: Studies of the effect of Helicobacter pylori treatment on gastric mucosa proliferation have yielded inconsistent results. We compared gastric mucosa cell proliferation posttherapy and in uninfected controls. METHODS: Biopsies were obtained from patients with H. pylori infection before treatment and at intervals for up to 33 months. Epithelial cell proliferation was determined using Ki-67 immunostaining. The labeling index (LI) is the proportion of positively labeled cells with respect to the total number of cells. The proliferative index was calculated by multiplying the labeling index (LI) and the proliferation zone PZ (PZ = length of the area between the uppermost and lowest labeled cells). RESULTS: The study included 27 patients with H. pylori gastritis and 35 controls. Epithelial cell proliferation (LI) was greater with H. pylori infection than without in both the antrum and corpus (65 ± 5 vs 91 ± 8 in the antrum and 44 ± 4 vs 72 ± 8 in the corpus, for uninfected controls vs H. pylori gastritis, respectively) (p = 0.0001). In the antrum there was no significant decrease in epithelial cell proliferation after cure of the H. pylori infection despite follow-up for >2 yr (labeling index = 83 ± 10). In contrast, epithelial cell proliferation decreased in the corpus and became similar to that in controls after 7-13 months. CONCLUSIONS: Patients with H. pylori infection have sustained high epithelial cell proliferation in the antrum compared to that in uninfected subjects. A continued increase in proliferation in the antrum after cure of H. pylori infection suggests continuing damage. (C) 2000 by Am. Coll. of Gastroenterology.

UR - http://www.scopus.com/inward/record.url?scp=0034035088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034035088&partnerID=8YFLogxK

U2 - 10.1016/S0002-9270(00)00724-3

DO - 10.1016/S0002-9270(00)00724-3

M3 - Article

C2 - 10763940

AN - SCOPUS:0034035088

VL - 95

SP - 930

EP - 935

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 4

ER -