Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin

Kristine S. Vogel, Luis F. Parada

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The proteins encoded by the p53 and Nf1 tumor suppressor genes are involved in cell signaling and regulation of proliferation during normal development and differentiation, as well as during tumor progression. To characterize the roles of these genes in the proliferation and survival of embryonic neurons, we have used dissociated cultures of sympathetic superior cervical ganglia (SCG) isolated from p53 and Nf1 single and compound-mutant mouse embryos. We have defined a temporal window for p53 involvement in sympathetic neuron survival and proliferation. Moreover, our results indicate that cooperativity between mutations. In Nf1 and p53 prolongs SCG neuron proliferation and increases the incidence of neural tube defects in compound- mutant embryos.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalMolecular and Cellular Neurosciences
Volume11
Issue number1-2
DOIs
StatePublished - May 1998

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Neurofibromin 1
Superior Cervical Ganglion
Neurons
Embryonic Structures
Sympathetic Ganglia
Neural Tube Defects
Tumor Suppressor Genes
Mutation
Incidence
Genes
Neoplasms
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin. / Vogel, Kristine S.; Parada, Luis F.

In: Molecular and Cellular Neurosciences, Vol. 11, No. 1-2, 05.1998, p. 19-28.

Research output: Contribution to journalArticle

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