TY - JOUR
T1 - Sympathetic stimulation, hemodynamic factors, and indices of cardiac inotropic state
AU - Galosy, R. A.
AU - Mitchell, Jere H
AU - Atkins, James M
AU - Reisch, J.
PY - 1978
Y1 - 1978
N2 - The influence of hemodynamic factors on indices of the inotropic state of the heart were studied before and during cardiac sympathetic nerve stimulation in 23 open-chested dogs anesthetized with sodium pentobarbital. Neural reflexes and the cardiovascular system remained intact during electrical stimulation of the left ventral ansa subclavian nerve. The influence of diastolic blood pressure (DBP), heart rate (HR), and left atrial pressure (LAP) on the maximal rate of left ventricular (LV dP/dt) and aortic pressure development (Ao dP/dt) were examined with multiple regression techniques. Diastolic blood pressure and LAP were found to be positively related to LV dP/dt during both control and nerve stimulation, with HR being negatively related to LV dP/dt during control periods, but positively related to LV dP/dt during nerve stimulation. Left atrial pressure and HR were observed to be positively related to Ao dP/dt during control and nerve stimulation, whereas DBP was negatively related to Ao dP/dt during control and nerve stimulation. A positive inotropic effect on the heart was evidenced during nerve stimulation in LV dP/dt and Ao dP/dt, regardless of the relationship with other variables. The results from these experiments indicate that both dP/dt and Ao dP/dt reflect changes in the inotropic state of the heart, but are not totally independent of intrinsic influences on cardiovascular performance of the heart.
AB - The influence of hemodynamic factors on indices of the inotropic state of the heart were studied before and during cardiac sympathetic nerve stimulation in 23 open-chested dogs anesthetized with sodium pentobarbital. Neural reflexes and the cardiovascular system remained intact during electrical stimulation of the left ventral ansa subclavian nerve. The influence of diastolic blood pressure (DBP), heart rate (HR), and left atrial pressure (LAP) on the maximal rate of left ventricular (LV dP/dt) and aortic pressure development (Ao dP/dt) were examined with multiple regression techniques. Diastolic blood pressure and LAP were found to be positively related to LV dP/dt during both control and nerve stimulation, with HR being negatively related to LV dP/dt during control periods, but positively related to LV dP/dt during nerve stimulation. Left atrial pressure and HR were observed to be positively related to Ao dP/dt during control and nerve stimulation, whereas DBP was negatively related to Ao dP/dt during control and nerve stimulation. A positive inotropic effect on the heart was evidenced during nerve stimulation in LV dP/dt and Ao dP/dt, regardless of the relationship with other variables. The results from these experiments indicate that both dP/dt and Ao dP/dt reflect changes in the inotropic state of the heart, but are not totally independent of intrinsic influences on cardiovascular performance of the heart.
UR - http://www.scopus.com/inward/record.url?scp=0018224452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018224452&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.1978.234.5.h562
DO - 10.1152/ajpheart.1978.234.5.h562
M3 - Article
C2 - 645922
AN - SCOPUS:0018224452
SN - 0363-6135
VL - 3
SP - H562-H566
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 5
ER -