Symptom severity and distress in advanced cancer

Jordanka Kirkova, Declan Walsh, Lisa Rybicki, Mellar P. Davis, Aynur Aktas, Jin Tao Jin, Jade Homsi

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We determined the relationship between symptom severity and distress for multiple cancer symptoms, and examined patient demographic influences on severity and distress in advanced cancer. A Cochran-Armitage trend test determined whether symptom distress increased with severity. Chi-square, Fishers exact test and logistic regression analysis examined moderate/severe (clinically important) and distressful symptoms by age (ĝ‰Currency sign65 versus >65), gender, primary site group, and ECOG performance status. Forty-six symptoms were analyzed in 181 individuals. More than 50% of individuals with clinically important symptoms rated them as distressful. The median percentage of individuals with mild but still distressful symptoms was 25%, with a range of 0% (bad dreams) to 73% (sore mouth). In both univariate and multivariate analysis, younger (ĝ‰Currency sign65 years) patients, females, and those with poor performance status had more clinically important and a higher prevalence of distressful symptoms (only anxiety was more frequently distressful to older individuals). Clinically important symptoms and two of those considered distressful varied by primary site group. After control for severity, symptom distress did not differ by primary site group. The prevalence of distress increased with greater symptom severity. Younger individuals, those with poor performance status, and females had greater symptom severity and distress. Mild symptoms were often distressful. After adjustment for severity, age, gender, and performance status all influenced symptom distress.

Original languageEnglish (US)
Pages (from-to)330-339
Number of pages10
JournalPalliative Medicine
Volume24
Issue number3
DOIs
StatePublished - Apr 1 2010

Fingerprint

Mouth
Neoplasms
Multivariate Analysis
Anxiety
Logistic Models
Regression Analysis
Demography

Keywords

  • Age
  • Distress
  • Gender
  • Performance status
  • Severity
  • Symptom

ASJC Scopus subject areas

  • Medicine(all)
  • Anesthesiology and Pain Medicine

Cite this

Kirkova, J., Walsh, D., Rybicki, L., Davis, M. P., Aktas, A., Tao Jin, J., & Homsi, J. (2010). Symptom severity and distress in advanced cancer. Palliative Medicine, 24(3), 330-339. https://doi.org/10.1177/0269216309356380

Symptom severity and distress in advanced cancer. / Kirkova, Jordanka; Walsh, Declan; Rybicki, Lisa; Davis, Mellar P.; Aktas, Aynur; Tao Jin, Jin; Homsi, Jade.

In: Palliative Medicine, Vol. 24, No. 3, 01.04.2010, p. 330-339.

Research output: Contribution to journalArticle

Kirkova, J, Walsh, D, Rybicki, L, Davis, MP, Aktas, A, Tao Jin, J & Homsi, J 2010, 'Symptom severity and distress in advanced cancer', Palliative Medicine, vol. 24, no. 3, pp. 330-339. https://doi.org/10.1177/0269216309356380
Kirkova J, Walsh D, Rybicki L, Davis MP, Aktas A, Tao Jin J et al. Symptom severity and distress in advanced cancer. Palliative Medicine. 2010 Apr 1;24(3):330-339. https://doi.org/10.1177/0269216309356380
Kirkova, Jordanka ; Walsh, Declan ; Rybicki, Lisa ; Davis, Mellar P. ; Aktas, Aynur ; Tao Jin, Jin ; Homsi, Jade. / Symptom severity and distress in advanced cancer. In: Palliative Medicine. 2010 ; Vol. 24, No. 3. pp. 330-339.
@article{fc8e9d03f7bb440cbb1986b033e6c090,
title = "Symptom severity and distress in advanced cancer",
abstract = "We determined the relationship between symptom severity and distress for multiple cancer symptoms, and examined patient demographic influences on severity and distress in advanced cancer. A Cochran-Armitage trend test determined whether symptom distress increased with severity. Chi-square, Fishers exact test and logistic regression analysis examined moderate/severe (clinically important) and distressful symptoms by age (ĝ‰Currency sign65 versus >65), gender, primary site group, and ECOG performance status. Forty-six symptoms were analyzed in 181 individuals. More than 50{\%} of individuals with clinically important symptoms rated them as distressful. The median percentage of individuals with mild but still distressful symptoms was 25{\%}, with a range of 0{\%} (bad dreams) to 73{\%} (sore mouth). In both univariate and multivariate analysis, younger (ĝ‰Currency sign65 years) patients, females, and those with poor performance status had more clinically important and a higher prevalence of distressful symptoms (only anxiety was more frequently distressful to older individuals). Clinically important symptoms and two of those considered distressful varied by primary site group. After control for severity, symptom distress did not differ by primary site group. The prevalence of distress increased with greater symptom severity. Younger individuals, those with poor performance status, and females had greater symptom severity and distress. Mild symptoms were often distressful. After adjustment for severity, age, gender, and performance status all influenced symptom distress.",
keywords = "Age, Distress, Gender, Performance status, Severity, Symptom",
author = "Jordanka Kirkova and Declan Walsh and Lisa Rybicki and Davis, {Mellar P.} and Aynur Aktas and {Tao Jin}, Jin and Jade Homsi",
year = "2010",
month = "4",
day = "1",
doi = "10.1177/0269216309356380",
language = "English (US)",
volume = "24",
pages = "330--339",
journal = "Palliative Medicine",
issn = "0269-2163",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Symptom severity and distress in advanced cancer

AU - Kirkova, Jordanka

AU - Walsh, Declan

AU - Rybicki, Lisa

AU - Davis, Mellar P.

AU - Aktas, Aynur

AU - Tao Jin, Jin

AU - Homsi, Jade

PY - 2010/4/1

Y1 - 2010/4/1

N2 - We determined the relationship between symptom severity and distress for multiple cancer symptoms, and examined patient demographic influences on severity and distress in advanced cancer. A Cochran-Armitage trend test determined whether symptom distress increased with severity. Chi-square, Fishers exact test and logistic regression analysis examined moderate/severe (clinically important) and distressful symptoms by age (ĝ‰Currency sign65 versus >65), gender, primary site group, and ECOG performance status. Forty-six symptoms were analyzed in 181 individuals. More than 50% of individuals with clinically important symptoms rated them as distressful. The median percentage of individuals with mild but still distressful symptoms was 25%, with a range of 0% (bad dreams) to 73% (sore mouth). In both univariate and multivariate analysis, younger (ĝ‰Currency sign65 years) patients, females, and those with poor performance status had more clinically important and a higher prevalence of distressful symptoms (only anxiety was more frequently distressful to older individuals). Clinically important symptoms and two of those considered distressful varied by primary site group. After control for severity, symptom distress did not differ by primary site group. The prevalence of distress increased with greater symptom severity. Younger individuals, those with poor performance status, and females had greater symptom severity and distress. Mild symptoms were often distressful. After adjustment for severity, age, gender, and performance status all influenced symptom distress.

AB - We determined the relationship between symptom severity and distress for multiple cancer symptoms, and examined patient demographic influences on severity and distress in advanced cancer. A Cochran-Armitage trend test determined whether symptom distress increased with severity. Chi-square, Fishers exact test and logistic regression analysis examined moderate/severe (clinically important) and distressful symptoms by age (ĝ‰Currency sign65 versus >65), gender, primary site group, and ECOG performance status. Forty-six symptoms were analyzed in 181 individuals. More than 50% of individuals with clinically important symptoms rated them as distressful. The median percentage of individuals with mild but still distressful symptoms was 25%, with a range of 0% (bad dreams) to 73% (sore mouth). In both univariate and multivariate analysis, younger (ĝ‰Currency sign65 years) patients, females, and those with poor performance status had more clinically important and a higher prevalence of distressful symptoms (only anxiety was more frequently distressful to older individuals). Clinically important symptoms and two of those considered distressful varied by primary site group. After control for severity, symptom distress did not differ by primary site group. The prevalence of distress increased with greater symptom severity. Younger individuals, those with poor performance status, and females had greater symptom severity and distress. Mild symptoms were often distressful. After adjustment for severity, age, gender, and performance status all influenced symptom distress.

KW - Age

KW - Distress

KW - Gender

KW - Performance status

KW - Severity

KW - Symptom

UR - http://www.scopus.com/inward/record.url?scp=77950613575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950613575&partnerID=8YFLogxK

U2 - 10.1177/0269216309356380

DO - 10.1177/0269216309356380

M3 - Article

C2 - 20015920

AN - SCOPUS:77950613575

VL - 24

SP - 330

EP - 339

JO - Palliative Medicine

JF - Palliative Medicine

SN - 0269-2163

IS - 3

ER -