TY - JOUR
T1 - Symptomatology and functional outcome in mild traumatic brain injury
T2 - Results from the prospective TRACK-TBI study
AU - McMahon, Paul
AU - Hricik, Allison
AU - Yue, John K.
AU - Puccio, Ava M.
AU - Inoue, Tomoo
AU - Lingsma, Hester F.
AU - Beers, Sue R.
AU - Gordon, Wayne A.
AU - Valadka, Alex B.
AU - Manley, Geoffrey T.
AU - Okonkwo, David O.
AU - Casey, Scott S.
AU - Cooper, Shelly R.
AU - Dams-O'Connor, Kristen
AU - Menon, David K.
AU - Sorani, Marco D.
AU - Yuh, Esther L.
AU - Mukherjee, Pratik
AU - Schnyer, David M.
AU - Vassar, Mary J.
PY - 2014
Y1 - 2014
N2 - Mild Traumatic Brain Injury (mTBI), or concussion, is a major public health concern. There is controversy in the literature regarding the true incidence of postconcussion syndrome (PCS), with the constellation of physical, cognitive, emotional, and sleep symptoms after mTBI. In the current study, we report on the incidence and evolution of PCS symptoms and patient outcomes after mTBI at 3, 6, and 12 months in a large, prospective cohort of mTBI patients. Participants were identified as part of the prospective, multi-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study. The study population was mTBI patients (Glasgow Coma Scale score of 13-15) presenting to the emergency department, including patients with a negative head computed tomography discharged to home without admission to hospital; 375 mTBI subjects were included in the analysis. At both 6 and 12 months after mTBI, 82% (n=250 of 305 and n=163 of 199, respectively) of patients reported at least one PCS symptom. Further, 44.5 and 40.3% of patients had significantly reduced Satisfaction With Life scores at 6 and 12 months, respectively. At 3 months after injury, 33% of the mTBI subjects were functionally impaired (Glasgow Outcome Scale-Extended score ≤6); 22.4% of the mTBI subjects available for follow-up were still below full functional status at 1 year after injury. The term "mild" continues to be a misnomer for this patient population and underscores the critical need for evolving classification strategies for TBI for targeted therapy.
AB - Mild Traumatic Brain Injury (mTBI), or concussion, is a major public health concern. There is controversy in the literature regarding the true incidence of postconcussion syndrome (PCS), with the constellation of physical, cognitive, emotional, and sleep symptoms after mTBI. In the current study, we report on the incidence and evolution of PCS symptoms and patient outcomes after mTBI at 3, 6, and 12 months in a large, prospective cohort of mTBI patients. Participants were identified as part of the prospective, multi-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study. The study population was mTBI patients (Glasgow Coma Scale score of 13-15) presenting to the emergency department, including patients with a negative head computed tomography discharged to home without admission to hospital; 375 mTBI subjects were included in the analysis. At both 6 and 12 months after mTBI, 82% (n=250 of 305 and n=163 of 199, respectively) of patients reported at least one PCS symptom. Further, 44.5 and 40.3% of patients had significantly reduced Satisfaction With Life scores at 6 and 12 months, respectively. At 3 months after injury, 33% of the mTBI subjects were functionally impaired (Glasgow Outcome Scale-Extended score ≤6); 22.4% of the mTBI subjects available for follow-up were still below full functional status at 1 year after injury. The term "mild" continues to be a misnomer for this patient population and underscores the critical need for evolving classification strategies for TBI for targeted therapy.
KW - clinical trial
KW - health-related quality of life
KW - outcome
KW - postconcussion syndrome
KW - traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=84892696960&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892696960&partnerID=8YFLogxK
U2 - 10.1089/neu.2013.2984
DO - 10.1089/neu.2013.2984
M3 - Article
C2 - 23952719
AN - SCOPUS:84892696960
SN - 0897-7151
VL - 31
SP - 26
EP - 33
JO - Journal of neurotrauma
JF - Journal of neurotrauma
IS - 1
ER -