Abstract
In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared ante-mortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 cases of AD. rCBF studies were performed using inhaled xenon gas (Xe-133), which yields quantitative results. Synapse loss was evaluated in postmortem brain samples using an enzyme-linked immunosorbant assay (ELISA) that measures synaptophysin, with results expressed as picomoles synaptophysin/10 mg brain. Synaptophysin was expressed either as concentration (QS method) or as the ratio of the concentration to the combined results in frontal, temporal and parietal lobe (RS method). There was no correlation between synapse loss and rCBF using the QS method and only borderline significance between right SPECT and right temporal synaptophysin using the RS method. The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD. Copyright
| Original language | English (US) |
|---|---|
| Pages (from-to) | 72-78 |
| Number of pages | 7 |
| Journal | Dementia and Geriatric Cognitive Disorders |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2003 |
Fingerprint
Keywords
- Alzheimer disease
- Cerebral blood flow, regional
- SPECT
- Synapse
- Synaptophysin
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Geriatrics and Gerontology
Cite this
Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease. / Bigio, Eileen H.; Reisch, Joan S.; White, Charles L.; Satumtira, Sivapong; Sontag, Estelle; Bonte, Frederick J.
In: Dementia and Geriatric Cognitive Disorders, Vol. 15, No. 2, 2003, p. 72-78.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease
AU - Bigio, Eileen H.
AU - Reisch, Joan S.
AU - White, Charles L.
AU - Satumtira, Sivapong
AU - Sontag, Estelle
AU - Bonte, Frederick J.
PY - 2003
Y1 - 2003
N2 - In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared ante-mortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 cases of AD. rCBF studies were performed using inhaled xenon gas (Xe-133), which yields quantitative results. Synapse loss was evaluated in postmortem brain samples using an enzyme-linked immunosorbant assay (ELISA) that measures synaptophysin, with results expressed as picomoles synaptophysin/10 mg brain. Synaptophysin was expressed either as concentration (QS method) or as the ratio of the concentration to the combined results in frontal, temporal and parietal lobe (RS method). There was no correlation between synapse loss and rCBF using the QS method and only borderline significance between right SPECT and right temporal synaptophysin using the RS method. The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD. Copyright
AB - In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared ante-mortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 cases of AD. rCBF studies were performed using inhaled xenon gas (Xe-133), which yields quantitative results. Synapse loss was evaluated in postmortem brain samples using an enzyme-linked immunosorbant assay (ELISA) that measures synaptophysin, with results expressed as picomoles synaptophysin/10 mg brain. Synaptophysin was expressed either as concentration (QS method) or as the ratio of the concentration to the combined results in frontal, temporal and parietal lobe (RS method). There was no correlation between synapse loss and rCBF using the QS method and only borderline significance between right SPECT and right temporal synaptophysin using the RS method. The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD. Copyright
KW - Alzheimer disease
KW - Cerebral blood flow, regional
KW - SPECT
KW - Synapse
KW - Synaptophysin
UR - http://www.scopus.com/inward/record.url?scp=0037234977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037234977&partnerID=8YFLogxK
U2 - 10.1159/000067970
DO - 10.1159/000067970
M3 - Article
VL - 15
SP - 72
EP - 78
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 2
ER -