Synaptic vesicle fusion

Jose Rizo-Rey, Christian Rosenmund

Research output: Contribution to journalReview article

367 Scopus citations

Abstract

The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion. In addition, SNARE complex assembly is likely orchestrated by Munc13s and RIMs, active-zone proteins that function in vesicle priming and diverse forms of presynaptic plasticity. Synaptotagmin-1 mediates triggering of release by Ca2+, probably through interactions with SNAREs and both membranes, as well as through a tight interplay with complexins. Elucidation of the release mechanism will require a full understanding of the network of interactions among all these proteins and the membranes.

Original languageEnglish (US)
Pages (from-to)665-674
Number of pages10
JournalNature Structural and Molecular Biology
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2008

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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