Diverse roles in membrane fusion have been proposed for the transmembrane regions (TMRs) of SNARE proteins, including formation of channel-like transmembrane pores. Reporting in Neuron, Zhou etal. (2013) show that lipid-anchored SNAREs lacking TMRs can support neurotransmitter release, suggesting that SNAREs function primarily as power engines that force membranes together.
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Developmental Biology
- Cell Biology