Synchrony drives motor cortex beta bursting,waveform dynamics, and phase-amplitude coupling in parkinson's disease

Andrew B. O'Keeffe, Mahsa Malekmohammadi, Hiro Sparks, Nader Pouratian

Research output: Contribution to journalArticlepeer-review

Abstract

Several lines of inquiry have separately identified beta oscillations, synchrony, waveform shape, and phase-amplitude coupling as important but sometimes inconsistent factors in the pathophysiology of Parkinson's disease. What has so far been lacking is a means by which these neurophysiological parameters are interrelated and how they relate to clinical symptomatology. To clarify the relationship among oscillatory power, bursting, synchrony, and phase-amplitude coupling, we recorded local field potentials/electrocorticography from hand motor and premotor cortical area in human subjects with c (N= 10) and Parkinson's disease (N= 22) during deep brain stimulator implantation surgery (14 females, 18 males). We show that motor cortical high beta oscillations in Parkinson's disease demonstrate increased burst durations relative to essential tremor patients. Notably, increased corticocortical synchrony between primary motor and premotor cortices precedes motor high beta bursts, suggesting a possible causal relationship between corticocortical synchrony and localized increases in beta power. We further show that high beta bursts are associated with significant changes in waveform shape and that beta-encoded phase-amplitude coupling is more evident during periods of high beta bursting. These findings reveal a deeper structure to the pathologic changes identified in the neurophysiology of Parkinson's disease, suggesting mechanisms by which the treatment may be enhanced using targeted network synchrony disruption approaches.

Original languageEnglish (US)
Pages (from-to)5833-5846
Number of pages14
JournalJournal of Neuroscience
Volume40
Issue number30
DOIs
StatePublished - Jul 22 2020
Externally publishedYes

Keywords

  • Deep Brain Stimulation
  • Electrocorticography
  • Motor Cortex
  • Phase Amplitude Coupling
  • Synchrony
  • Waveform Analysis

ASJC Scopus subject areas

  • Neuroscience(all)

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