Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas

S. Sakamoto; H. Taga; T. Uchikoshi; H. Kudo; S. Suzuki; Y. Sugiura; K. Kuwa; Y. Endo

Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas

S. Sakamoto, H. Taga, T. Uchikoshi, H. Kudo, S. Suzuki, Y. Sugiura, K. Kuwa, Y. Endo

Neuroscience

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We investigated the synergistic efficacy of CDDP and UFT, an oral anticancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-induced hepatocarcinomas in rats. Chronic treatment with CDDP slightly reduced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activities, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in hepatocarcinomas.

Original language	English (US)
Pages (from-to)	631-634
Number of pages	4
Journal	Anticancer Research
Volume	13
Issue number	3
State	Published - 1993

Keywords

Hepatocarcinoma
Thymidine kinase
Thymidylate synthetase
UFT

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas",

abstract = "We investigated the synergistic efficacy of CDDP and UFT, an oral anticancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-induced hepatocarcinomas in rats. Chronic treatment with CDDP slightly reduced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activities, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in hepatocarcinomas.",

keywords = "Hepatocarcinoma, Thymidine kinase, Thymidylate synthetase, UFT",

author = "S. Sakamoto and H. Taga and T. Uchikoshi and H. Kudo and S. Suzuki and Y. Sugiura and K. Kuwa and Y. Endo",

year = "1993",

language = "English (US)",

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journal = "Anticancer Research",

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T1 - Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas

AU - Sakamoto, S.

AU - Taga, H.

AU - Uchikoshi, T.

AU - Kudo, H.

AU - Suzuki, S.

AU - Sugiura, Y.

AU - Kuwa, K.

AU - Endo, Y.

PY - 1993

Y1 - 1993

N2 - We investigated the synergistic efficacy of CDDP and UFT, an oral anticancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-induced hepatocarcinomas in rats. Chronic treatment with CDDP slightly reduced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activities, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in hepatocarcinomas.

AB - We investigated the synergistic efficacy of CDDP and UFT, an oral anticancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-induced hepatocarcinomas in rats. Chronic treatment with CDDP slightly reduced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activities, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in hepatocarcinomas.

KW - Hepatocarcinoma

KW - Thymidine kinase

KW - Thymidylate synthetase

KW - UFT

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M3 - Article

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AN - SCOPUS:0027279968

SN - 0250-7005

VL - 13

SP - 631

EP - 634

JO - Anticancer Research

JF - Anticancer Research

IS - 3

ER -

Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas

Abstract

Keywords

ASJC Scopus subject areas

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