Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas

S. Sakamoto, H. Taga, T. Uchikoshi, H. Kudo, S. Suzuki, Y. Sugiura, K. Kuwa, Y. Endo

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We investigated the synergistic efficacy of CDDP and UFT, an oral anticancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-induced hepatocarcinomas in rats. Chronic treatment with CDDP slightly reduced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activities, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in hepatocarcinomas.

Original languageEnglish (US)
Pages (from-to)631-634
Number of pages4
JournalAnticancer Research
Volume13
Issue number3
StatePublished - Jan 1 1993

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Keywords

  • Hepatocarcinoma
  • Thymidine kinase
  • Thymidylate synthetase
  • UFT

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sakamoto, S., Taga, H., Uchikoshi, T., Kudo, H., Suzuki, S., Sugiura, Y., Kuwa, K., & Endo, Y. (1993). Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas. Anticancer Research, 13(3), 631-634.