Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas

S. Sakamoto, H. Taga, T. Uchikoshi, H. Kudo, S. Suzuki, Y. Sugiura, K. Kuwa, Y. Endo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated the synergistic efficacy of CDDP and UFT, an oral anticancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-induced hepatocarcinomas in rats. Chronic treatment with CDDP slightly reduced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activities, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in hepatocarcinomas.

Original languageEnglish (US)
Pages (from-to)631-634
Number of pages4
JournalAnticancer Research
Volume13
Issue number3
StatePublished - 1993

Fingerprint

dTMP kinase
Cisplatin
Methyldimethylaminoazobenzene
Thymidylate Synthase
Thymidine Kinase
DNA
Fluorouracil
Enzymes

Keywords

  • Hepatocarcinoma
  • Thymidine kinase
  • Thymidylate synthetase
  • UFT

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sakamoto, S., Taga, H., Uchikoshi, T., Kudo, H., Suzuki, S., Sugiura, Y., ... Endo, Y. (1993). Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas. Anticancer Research, 13(3), 631-634.

Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas. / Sakamoto, S.; Taga, H.; Uchikoshi, T.; Kudo, H.; Suzuki, S.; Sugiura, Y.; Kuwa, K.; Endo, Y.

In: Anticancer Research, Vol. 13, No. 3, 1993, p. 631-634.

Research output: Contribution to journalArticle

Sakamoto, S, Taga, H, Uchikoshi, T, Kudo, H, Suzuki, S, Sugiura, Y, Kuwa, K & Endo, Y 1993, 'Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas', Anticancer Research, vol. 13, no. 3, pp. 631-634.
Sakamoto S, Taga H, Uchikoshi T, Kudo H, Suzuki S, Sugiura Y et al. Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas. Anticancer Research. 1993;13(3):631-634.
Sakamoto, S. ; Taga, H. ; Uchikoshi, T. ; Kudo, H. ; Suzuki, S. ; Sugiura, Y. ; Kuwa, K. ; Endo, Y. / Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas. In: Anticancer Research. 1993 ; Vol. 13, No. 3. pp. 631-634.
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