Synergy between adjuvant arthritis and collagen-induced arthritis in rats

J. D. Taurog, S. S. Kerwar, R. A. McReynolds, G. P. Sandberg, S. L. Leary, M. L. Mahowald

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Abstract

Adjuvant arthritis (AA) in rats is susceptible to cell-mediated passive transfer. Collagen-induced arthritis (CIA) in rats is susceptible to passive transfer with antibody to type II collagen. We report here the development of strikingly severe arthritis in Lewis rats as the result of synergy between passively transferred antibody to type II collagen from rats with CIA and concanavalin A (Con A)-stimulated lymph node or spleen cells from syngeneic rats with AA. Similar synergy was seen in rats with AA given anticollagen antibody, in rats with CIA given Con A-stimulated adjuvant spleen cells, and in rats actively immunized with CII and complete Freund's adjuvant. The synergistic process caused a very severe polyarthritis, characterized by marked swelling and erythema in all the joints of the distal extremities, with histologic and radiographic evidence of early, extensive erosion of articular cartilage. Synergy was apparent if the lymphoid cell from AA rats were given up to 1 mo after a single injection of anticollagen antibody. No synergy was seen when normal rat immunoglobulin or antiovalbumin antibody was substituted for anticollagen antibody, when Con A-stimulated lymphoid cells from normal rats or donors with CIA were used, or when Con-A stimulated AA lymphoid cells were irradiated before transfer. Synergy between separate immune effector mechanisms may represent a general phenomenon in the pathogenesis of inflammatory joint disease.

Original languageEnglish (US)
Pages (from-to)962-978
Number of pages17
JournalJournal of Experimental Medicine
Volume162
Issue number3
DOIs
StatePublished - 1985

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Experimental Arthritis
Concanavalin A
Antibodies
Collagen Type II
Lymphocytes
Arthritis
Spleen
Passive Immunization
Freund's Adjuvant
Joint Diseases
Articular Cartilage
Erythema
Immunoglobulins
Extremities
Joints
Lymph Nodes

ASJC Scopus subject areas

  • Immunology

Cite this

Taurog, J. D., Kerwar, S. S., McReynolds, R. A., Sandberg, G. P., Leary, S. L., & Mahowald, M. L. (1985). Synergy between adjuvant arthritis and collagen-induced arthritis in rats. Journal of Experimental Medicine, 162(3), 962-978. https://doi.org/10.1084/jem.162.3.962

Synergy between adjuvant arthritis and collagen-induced arthritis in rats. / Taurog, J. D.; Kerwar, S. S.; McReynolds, R. A.; Sandberg, G. P.; Leary, S. L.; Mahowald, M. L.

In: Journal of Experimental Medicine, Vol. 162, No. 3, 1985, p. 962-978.

Research output: Contribution to journalArticle

Taurog, JD, Kerwar, SS, McReynolds, RA, Sandberg, GP, Leary, SL & Mahowald, ML 1985, 'Synergy between adjuvant arthritis and collagen-induced arthritis in rats', Journal of Experimental Medicine, vol. 162, no. 3, pp. 962-978. https://doi.org/10.1084/jem.162.3.962
Taurog, J. D. ; Kerwar, S. S. ; McReynolds, R. A. ; Sandberg, G. P. ; Leary, S. L. ; Mahowald, M. L. / Synergy between adjuvant arthritis and collagen-induced arthritis in rats. In: Journal of Experimental Medicine. 1985 ; Vol. 162, No. 3. pp. 962-978.
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