Synthesis and characterization of a macrocyclic near-infrared optical scaffold

Yunpeng Ye; Wen Ping Li; Carolyn J. Anderson; Jeffery Kao; Gregory V. Nikiforovich; Samuel Achilefu

doi:10.1021/ja034186o

Synthesis and characterization of a macrocyclic near-infrared optical scaffold

Yunpeng Ye, Wen Ping Li, Carolyn J. Anderson, Jeffery Kao, Gregory V. Nikiforovich, Samuel Achilefu

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Macrocyclization of a bioactive peptide with a bifunctional near-infrared fluorescent optical probe gives a compound that retained the receptor binding affinity of the peptide and the photophysical properties of the optical probe. The robust nature of the new compound provides a structural framework for optimizing the activity of bioactive molecules and for monitoring chemical or biological processes in vivo and in vitro by near-infrared optical methods.

Original language	English (US)
Pages (from-to)	7766-7767
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	26
DOIs	https://doi.org/10.1021/ja034186o
State	Published - Jul 2 2003
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja034186o

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title = "Synthesis and characterization of a macrocyclic near-infrared optical scaffold",

abstract = "Macrocyclization of a bioactive peptide with a bifunctional near-infrared fluorescent optical probe gives a compound that retained the receptor binding affinity of the peptide and the photophysical properties of the optical probe. The robust nature of the new compound provides a structural framework for optimizing the activity of bioactive molecules and for monitoring chemical or biological processes in vivo and in vitro by near-infrared optical methods.",

author = "Yunpeng Ye and Li, {Wen Ping} and Anderson, {Carolyn J.} and Jeffery Kao and Nikiforovich, {Gregory V.} and Samuel Achilefu",

year = "2003",

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doi = "10.1021/ja034186o",

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AU - Ye, Yunpeng

AU - Li, Wen Ping

AU - Anderson, Carolyn J.

AU - Kao, Jeffery

AU - Nikiforovich, Gregory V.

AU - Achilefu, Samuel

PY - 2003/7/2

Y1 - 2003/7/2

N2 - Macrocyclization of a bioactive peptide with a bifunctional near-infrared fluorescent optical probe gives a compound that retained the receptor binding affinity of the peptide and the photophysical properties of the optical probe. The robust nature of the new compound provides a structural framework for optimizing the activity of bioactive molecules and for monitoring chemical or biological processes in vivo and in vitro by near-infrared optical methods.

AB - Macrocyclization of a bioactive peptide with a bifunctional near-infrared fluorescent optical probe gives a compound that retained the receptor binding affinity of the peptide and the photophysical properties of the optical probe. The robust nature of the new compound provides a structural framework for optimizing the activity of bioactive molecules and for monitoring chemical or biological processes in vivo and in vitro by near-infrared optical methods.

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Synthesis and characterization of a macrocyclic near-infrared optical scaffold

Abstract

ASJC Scopus subject areas

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