Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: Cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells

Haiyuan Zhang; Ronald Thomas; David Oupicky; Fangyu Peng

doi:10.1007/s00775-007-0299-6

Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: Cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells

Haiyuan Zhang, Ronald Thomas, David Oupicky, Fangyu Peng

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Two new copper thiosemicarbazone complexes with an ONNS quadridentate system were synthesized and evaluated for anticancer activity on cisplatin-resistant neuroblastoma cells. Among these two copper complexes, the substituted 8-hydroxyquinoline-2-carboxaldehyde-4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) exhibited stronger cell growth inhibition activity than the unsubstituted copper 8-hydroxyquinoline-2-carboxaldehyde thiosemicarbazide complex (CuHQTS). Both CuHQTS and CuHQDMTS showed dose-dependent cell growth inhibition, cell cycle arrest and apoptosis induction activities on the SK-N-DZ neuroblastoma cells. Increased expression of p53 protein molecules was detected in the SK-N-DZ cells treated with CuHQTS. The data obtained in this study suggest that CuHQDMTS and CuHQTS hold potential as new, effective drugs for treatment of refractory neuroblastoma in children.

Original language	English (US)
Pages (from-to)	47-55
Number of pages	9
Journal	Journal of Biological Inorganic Chemistry
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/s00775-007-0299-6
State	Published - Jan 2008

Keywords

Apoptosis
Cell cycle arrest
Copper
Proliferation inhibition
Thiosemicarbazone

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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Zhang, H., Thomas, R., Oupicky, D., & Peng, F. (2008). Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: Cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells. Journal of Biological Inorganic Chemistry, 13(1), 47-55. https://doi.org/10.1007/s00775-007-0299-6

Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: Cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells. / Zhang, Haiyuan; Thomas, Ronald; Oupicky, David et al.
In: Journal of Biological Inorganic Chemistry, Vol. 13, No. 1, 01.2008, p. 47-55.

Research output: Contribution to journal › Article › peer-review

Zhang, H, Thomas, R, Oupicky, D & Peng, F 2008, 'Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: Cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells', Journal of Biological Inorganic Chemistry, vol. 13, no. 1, pp. 47-55. https://doi.org/10.1007/s00775-007-0299-6

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abstract = "Two new copper thiosemicarbazone complexes with an ONNS quadridentate system were synthesized and evaluated for anticancer activity on cisplatin-resistant neuroblastoma cells. Among these two copper complexes, the substituted 8-hydroxyquinoline-2-carboxaldehyde-4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) exhibited stronger cell growth inhibition activity than the unsubstituted copper 8-hydroxyquinoline-2-carboxaldehyde thiosemicarbazide complex (CuHQTS). Both CuHQTS and CuHQDMTS showed dose-dependent cell growth inhibition, cell cycle arrest and apoptosis induction activities on the SK-N-DZ neuroblastoma cells. Increased expression of p53 protein molecules was detected in the SK-N-DZ cells treated with CuHQTS. The data obtained in this study suggest that CuHQDMTS and CuHQTS hold potential as new, effective drugs for treatment of refractory neuroblastoma in children.",

keywords = "Apoptosis, Cell cycle arrest, Copper, Proliferation inhibition, Thiosemicarbazone",

author = "Haiyuan Zhang and Ronald Thomas and David Oupicky and Fangyu Peng",

note = "Funding Information: Acknowledgements We thank Claudio Verani for help in chemical characterization of the complexes and Jiu-sheng Wu for technical assistance. This project was partly funded by a faculty research development award from the Carman and Ann Adams Foundation and a new investigator award from Fighting Children{\textquoteright}s Cancer Foundation to Fangyu Peng. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

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AB - Two new copper thiosemicarbazone complexes with an ONNS quadridentate system were synthesized and evaluated for anticancer activity on cisplatin-resistant neuroblastoma cells. Among these two copper complexes, the substituted 8-hydroxyquinoline-2-carboxaldehyde-4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) exhibited stronger cell growth inhibition activity than the unsubstituted copper 8-hydroxyquinoline-2-carboxaldehyde thiosemicarbazide complex (CuHQTS). Both CuHQTS and CuHQDMTS showed dose-dependent cell growth inhibition, cell cycle arrest and apoptosis induction activities on the SK-N-DZ neuroblastoma cells. Increased expression of p53 protein molecules was detected in the SK-N-DZ cells treated with CuHQTS. The data obtained in this study suggest that CuHQDMTS and CuHQTS hold potential as new, effective drugs for treatment of refractory neuroblastoma in children.

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Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: Cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells

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