Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities

Dan Rusu, Andreea Stanila, Iliu Ovidiu Marian, Calin Ovidiu Marian, Mariana Rusu, Roxana Lucaciu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cobalt-amino acids complexes in aqueous solution: [Co-(L H 1O)2]×H2O (1), (L1=lysine), [Co- (L2H2O)J×.H2O (2), (L 2=Ieucine) and [Co(L3H2O)]×2H 2O (3), (L3=methionine) were synthesized and characterized by means of elemental, thermal ana IR, UV-VIS, and EPR spectroscopic investigations, and biological measurements. The IR spectra show that amino acids act as bidentate ligands with coordination involving the carboxylic oxygen and the nitrogen atom of the amino group. The v(C=O), v(N-H), and 5(N- H) vibrations are shifted toward higher frequencies for complexes comparable with ligands. Visible electronic and powder EPR spectres at room temperature are typical for monomeric species with octahedric local symmetry around the metal ion. The biological testing of the synthesized complexes was done to see citotoxic activity that might show on cell cultures of Sacharomices cerevisiae and Candida albicans.

Original languageEnglish (US)
Pages (from-to)939-943
Number of pages5
JournalRevista de Chimie
Volume60
Issue number9
StatePublished - Sep 2009

Fingerprint

Cobalt
Bioactivity
Paramagnetic resonance
Ligands
Amino Acids
Candida
Cell culture
Methionine
Powders
Lysine
Metal ions
Nitrogen
Oxygen
Atoms
Testing
Temperature
Hot Temperature

Keywords

  • Amino acids
  • Biological testing
  • Co(II) complexes
  • FT-IR/UV-VIS/EPR spectroscopy

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Rusu, D., Stanila, A., Marian, I. O., Marian, C. O., Rusu, M., & Lucaciu, R. (2009). Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities. Revista de Chimie, 60(9), 939-943.

Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities. / Rusu, Dan; Stanila, Andreea; Marian, Iliu Ovidiu; Marian, Calin Ovidiu; Rusu, Mariana; Lucaciu, Roxana.

In: Revista de Chimie, Vol. 60, No. 9, 09.2009, p. 939-943.

Research output: Contribution to journalArticle

Rusu, D, Stanila, A, Marian, IO, Marian, CO, Rusu, M & Lucaciu, R 2009, 'Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities', Revista de Chimie, vol. 60, no. 9, pp. 939-943.
Rusu D, Stanila A, Marian IO, Marian CO, Rusu M, Lucaciu R. Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities. Revista de Chimie. 2009 Sep;60(9):939-943.
Rusu, Dan ; Stanila, Andreea ; Marian, Iliu Ovidiu ; Marian, Calin Ovidiu ; Rusu, Mariana ; Lucaciu, Roxana. / Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities. In: Revista de Chimie. 2009 ; Vol. 60, No. 9. pp. 939-943.
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