Synthesis and characterization of theranostic poly(HPMA)-c(RGDyK)-DOTA- 64Cu copolymer targeting tumor angiogenesis: Tumor localization visualized by positron emission tomography

Jianchao Yuan, Haiyuan Zhang, Harpreet Kaur, David Oupicky, Fangyu Peng

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymers were synthesized and characterized for tumor localization in vivo as a theranostic scaffold for cancer imaging and anticancer drug delivery targeting tumor angiogenesis. Tumor localization of the poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymers was visualized in mice bearing human prostate cancer xenografts by positron emission tomography (PET) using a microPET scanner. PET quantitative analysis demonstrated that tumor 64Cu radioactivity (2.75 ± 0.34%ID/g) in tumor-bearing mice 3 hours following intravenous injection of the poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymers was significantly higher than the tumor 64Cu radioactivity (1.29 ± 0.26%ID/g) in tumor-bearing mice injected with the nontargeted poly(HPMA)-DOTA-64Cu copolymers (p = .004). The poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymers hold potential as a theranostic scaffold for cancer imaging and radiochemotherapy of prostate cancer targeting tumor angiogenesis by noninvasive tracking with PET.

Original languageEnglish (US)
JournalMolecular Imaging
Volume12
Issue number3
DOIs
StatePublished - May 2013

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hydroxypropyl methacrylate
angiogenesis
Positron emission tomography
Positron-Emission Tomography
Tumors
positrons
copolymers
tumors
Copolymers
tomography
Bearings (structural)
synthesis
Neoplasms
cancer
mice
Radioactivity
radioactivity
Scaffolds
Prostatic Neoplasms
Imaging techniques

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Biotechnology
  • Molecular Medicine
  • Biomedical Engineering
  • Condensed Matter Physics

Cite this

Synthesis and characterization of theranostic poly(HPMA)-c(RGDyK)-DOTA- 64Cu copolymer targeting tumor angiogenesis : Tumor localization visualized by positron emission tomography. / Yuan, Jianchao; Zhang, Haiyuan; Kaur, Harpreet; Oupicky, David; Peng, Fangyu.

In: Molecular Imaging, Vol. 12, No. 3, 05.2013.

Research output: Contribution to journalArticle

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