TY - JOUR
T1 - Synthesis and evaluation of technetium-99m monocationic mixed ligand complexes of phenyl substituted/condensed tetradentate schiff's bases and trimethylphosphine
AU - Goomer, N. C.
AU - Kulkarni, P. V.
AU - Constantinescu, A.
AU - Antich, P.
AU - Parkey, R. W.
AU - Corbett, J. R.
N1 - Funding Information:
Acknowledgemenrs-N.C . Goomer, one of the authors, gratefullya cknowledgeas grant of study leave from the Board of Radiation& IsotopeT echnology,B ombay,I ndia and the award of a fellowship from the Departmento f Radiology, University of Texas SouthwesternM edical Center, Dallas, Tex., U.S.A. The authors thank Cathy Starnesf or typing the manuscript,
PY - 1992/8
Y1 - 1992/8
N2 - Tc-99m monocationic mixed ligand complexes of phenyl substituted/condensed Schiff's bases, N,N′-ethylene-bis-(benzoylacetone imine) (Lb) or N,N′-ethylene-bis-(salicylaldehyde imine) (Lc) or N,N′-ethylene-bis-(2-hydroxyacetophenone imine) (Ld) and trimethylphosphine were synthesized to determine the influence of the presence of a phenyl group in these tracers on their heart uptake in rats. A new formulation procedure using aq. β-hydroxypropylcyclodextrin (HPB) solution was developed for intravenous administration of nonpolar 99mTc complexes. Comparison of biodistribution data for the reference 99mTc complex from N,N′-ethylene-bis-(acetylacetone imine) and trimethylphosphine using HPB formulation and alternate formulation (0.9% saline) showed the same results. Biodistribution of the title 99mTc complexes, [99mTc Lb (PMe3)2]+, [99mTc Lc (PMe3)2]+ and [99mTc Ld (PMe3)2]+ showed heart-to-blood activity ratios of 1.7, 2.1 and 1.7, respectively, at 15 min post-injection in rats.
AB - Tc-99m monocationic mixed ligand complexes of phenyl substituted/condensed Schiff's bases, N,N′-ethylene-bis-(benzoylacetone imine) (Lb) or N,N′-ethylene-bis-(salicylaldehyde imine) (Lc) or N,N′-ethylene-bis-(2-hydroxyacetophenone imine) (Ld) and trimethylphosphine were synthesized to determine the influence of the presence of a phenyl group in these tracers on their heart uptake in rats. A new formulation procedure using aq. β-hydroxypropylcyclodextrin (HPB) solution was developed for intravenous administration of nonpolar 99mTc complexes. Comparison of biodistribution data for the reference 99mTc complex from N,N′-ethylene-bis-(acetylacetone imine) and trimethylphosphine using HPB formulation and alternate formulation (0.9% saline) showed the same results. Biodistribution of the title 99mTc complexes, [99mTc Lb (PMe3)2]+, [99mTc Lc (PMe3)2]+ and [99mTc Ld (PMe3)2]+ showed heart-to-blood activity ratios of 1.7, 2.1 and 1.7, respectively, at 15 min post-injection in rats.
UR - http://www.scopus.com/inward/record.url?scp=44049111900&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44049111900&partnerID=8YFLogxK
U2 - 10.1016/0883-2897(92)90102-5
DO - 10.1016/0883-2897(92)90102-5
M3 - Article
C2 - 1522022
AN - SCOPUS:44049111900
SN - 0883-2897
VL - 19
SP - 679
EP - 684
JO - International Journal of Radiation Applications and Instrumentation.
JF - International Journal of Radiation Applications and Instrumentation.
IS - 6
ER -