(equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Dec 28 2000|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry