Abstract
(equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.
Original language | English (US) |
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Pages (from-to) | 4241-4243 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 2 |
Issue number | 26 |
DOIs | |
State | Published - Dec 28 2000 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry