Synthesis and initial structure-activity relationships of modified salicylihalamides

Yusheng Wu; Olga R. Seguil; Jef K. De Brabander

doi:10.1021/ol0068086

Synthesis and initial structure-activity relationships of modified salicylihalamides

Yusheng Wu, Olga R. Seguil, Jef K. De Brabander

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

(equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.

Original language	English (US)
Pages (from-to)	4241-4243
Number of pages	3
Journal	Organic Letters
Volume	2
Issue number	26
DOIs	https://doi.org/10.1021/ol0068086
State	Published - Dec 28 2000

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Synthesis and initial structure-activity relationships of modified salicylihalamides",

abstract = "(equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.",

author = "Yusheng Wu and Seguil, {Olga R.} and {De Brabander}, {Jef K.}",

year = "2000",

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doi = "10.1021/ol0068086",

language = "English (US)",

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journal = "Organic Letters",

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publisher = "American Chemical Society",

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AU - Wu, Yusheng

AU - Seguil, Olga R.

AU - De Brabander, Jef K.

PY - 2000/12/28

Y1 - 2000/12/28

N2 - (equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.

AB - (equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.

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JO - Organic Letters

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Synthesis and initial structure-activity relationships of modified salicylihalamides

Abstract

ASJC Scopus subject areas

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