Abstract
(equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4241-4243 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 2 |
| Issue number | 26 |
| State | Published - Dec 28 2000 |
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ASJC Scopus subject areas
- Molecular Medicine
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Synthesis and initial structure-activity relationships of modified salicylihalamides. / Wu, Yusheng; Seguil, Olga R.; De Brabander, Jef K.
In: Organic Letters, Vol. 2, No. 26, 28.12.2000, p. 4241-4243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and initial structure-activity relationships of modified salicylihalamides
AU - Wu, Yusheng
AU - Seguil, Olga R.
AU - De Brabander, Jef K.
PY - 2000/12/28
Y1 - 2000/12/28
N2 - (equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.
AB - (equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.
UR - http://www.scopus.com/inward/record.url?scp=0034727948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034727948&partnerID=8YFLogxK
M3 - Article
C2 - 11150209
AN - SCOPUS:0034727948
VL - 2
SP - 4241
EP - 4243
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 26
ER -