Synthesis and initial structure-activity relationships of modified salicylihalamides

Yusheng Wu, Olga R. Seguil, Jef K. De Brabander

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

(equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.

Original languageEnglish (US)
Pages (from-to)4241-4243
Number of pages3
JournalOrganic Letters
Volume2
Issue number26
StatePublished - Dec 28 2000

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congeners
Structure-Activity Relationship
cultured cells
Melanoma
cancer
Cells
Throughput
Cell Line
synthesis
Growth
Neoplasms
Experiments
salicylihalamide A

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Synthesis and initial structure-activity relationships of modified salicylihalamides. / Wu, Yusheng; Seguil, Olga R.; De Brabander, Jef K.

In: Organic Letters, Vol. 2, No. 26, 28.12.2000, p. 4241-4243.

Research output: Contribution to journalArticle

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