Synthesis and initial structure-activity relationships of modified salicylihalamides

Yusheng Wu, Olga R. Seguil, Jef K. De Brabander

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

(equation presented) The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.

Original languageEnglish (US)
Pages (from-to)4241-4243
Number of pages3
JournalOrganic Letters
Volume2
Issue number26
DOIs
StatePublished - Dec 28 2000

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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