Synthesis and membrane permeability of PNA-peptide conjugates

Carla G. Simmons; Anne E. Pitts; Lynn D. Mayfield; Jerry W. Shay; David R. Corey

doi:10.1016/S0960-894X(97)10136-6

Synthesis and membrane permeability of PNA-peptide conjugates

Carla G. Simmons, Anne E. Pitts, Lynn D. Mayfield, Jerry W. Shay, David R. Corey

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Chimeric molecules consisting of peptide nucleic acid oligomers (PNAs) and peptides derived from the third helix of the homeodomain of Antennapedia are taken up by mammalian cells in culture. Uptake is independent of orientation and occurs with high efficiency, suggesting that peptide conjugates are a promising strategy for intracellular PNA delivery.

Original language	English (US)
Pages (from-to)	3001-3006
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(97)10136-6
State	Published - Dec 2 1997

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(97)10136-6

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abstract = "Chimeric molecules consisting of peptide nucleic acid oligomers (PNAs) and peptides derived from the third helix of the homeodomain of Antennapedia are taken up by mammalian cells in culture. Uptake is independent of orientation and occurs with high efficiency, suggesting that peptide conjugates are a promising strategy for intracellular PNA delivery.",

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AU - Pitts, Anne E.

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AU - Shay, Jerry W.

AU - Corey, David R.

PY - 1997/12/2

Y1 - 1997/12/2

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AB - Chimeric molecules consisting of peptide nucleic acid oligomers (PNAs) and peptides derived from the third helix of the homeodomain of Antennapedia are taken up by mammalian cells in culture. Uptake is independent of orientation and occurs with high efficiency, suggesting that peptide conjugates are a promising strategy for intracellular PNA delivery.

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Synthesis and membrane permeability of PNA-peptide conjugates

Abstract

ASJC Scopus subject areas

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