Synthesis and membrane permeability of PNA-peptide conjugates

Carla G. Simmons, Anne E. Pitts, Lynn D. Mayfield, Jerry W. Shay, David R. Corey

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Chimeric molecules consisting of peptide nucleic acid oligomers (PNAs) and peptides derived from the third helix of the homeodomain of Antennapedia are taken up by mammalian cells in culture. Uptake is independent of orientation and occurs with high efficiency, suggesting that peptide conjugates are a promising strategy for intracellular PNA delivery.

Original languageEnglish (US)
Pages (from-to)3001-3006
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number23
DOIs
StatePublished - Dec 2 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis and membrane permeability of PNA-peptide conjugates'. Together they form a unique fingerprint.

  • Cite this