Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease

Neil Vasdev, Pengpeng Cao, Erik M. Van Oosten, Alan A. Wilson, Sylvain Houle, Guiyang Hao, Xiankai Sun, Nikolai Slavine, Mustafa Alhasan, Peter P. Antich, Frederick J. Bonte, Padmakar Kulkarni

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Benzyloxy-2-chloroquinoline was reacted with fluorine-18 labelled potassium cryptand fluoride, followed by catalytic hydrogenation to prepare [ 18F]2-fluoroquinolin-8-ol in high radiochemical yields (30%; uncorrected and relative to [18F]-fluoride), specific activities (>1 Ci μmol-1) and radiochemical purities (>99%) within 70 min; PET-CT imaging with this new radiotracer in double transgenic mice shows excellent promise for imaging Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)1228-1230
Number of pages3
JournalMedChemComm
Volume3
Issue number10
DOIs
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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    Vasdev, N., Cao, P., Van Oosten, E. M., Wilson, A. A., Houle, S., Hao, G., Sun, X., Slavine, N., Alhasan, M., Antich, P. P., Bonte, F. J., & Kulkarni, P. (2012). Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease. MedChemComm, 3(10), 1228-1230. https://doi.org/10.1039/c2md20075a