Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues

Man Fai Wong, Joyce J. Repa, Margaret Clagett-Dame, Robert W. Curley

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In an effort to synthesize two conformationally restricted retinoids utilizing a cyclopropyl ring as bioisostere for the C9-C10 double bond, we describe the synthetic strategies and retinoid receptor binding affinity of the trans-cyclopropyl analogue and the unexpected epimerization of the cis-cyclopropyl analogue.

Original languageEnglish (US)
Pages (from-to)2313-2318
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number17
DOIs
StatePublished - Sep 9 1997

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Retinoids
Tretinoin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues. / Wong, Man Fai; Repa, Joyce J.; Clagett-Dame, Margaret; Curley, Robert W.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 17, 09.09.1997, p. 2313-2318.

Research output: Contribution to journalArticle

Wong, Man Fai ; Repa, Joyce J. ; Clagett-Dame, Margaret ; Curley, Robert W. / Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 17. pp. 2313-2318.
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