Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues

Man Fai Wong, Joyce J. Repa, Margaret Clagett-Dame, Robert W. Curley

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

In an effort to synthesize two conformationally restricted retinoids utilizing a cyclopropyl ring as bioisostere for the C9-C10 double bond, we describe the synthetic strategies and retinoid receptor binding affinity of the trans-cyclopropyl analogue and the unexpected epimerization of the cis-cyclopropyl analogue.

Original languageEnglish (US)
Pages (from-to)2313-2318
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number17
DOIs
StatePublished - Sep 9 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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