Synthesis, crystal structures and in vitro anticancer activities of two copper(II) coordination compounds

Helen Wang, Maurice Sorolla, Xiqu Wang, Allan J. Jacobson, Hongyu Wang, Anil K Pillai

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Abstract

Two new Cu(II) coordination compounds, [Cu2(cca)(phen)4](ClO4)2(H2O)5.5, 1, and [Cu2(OH)(oda)(phen)2)](ClO4), 2, where cca = 4-carboxycinnamate; phen = 1,10-phenanthroline; oda = octanedioate, have been synthesized and their structures determined by single-crystal X-ray diffraction. Compound 1 contains cationic Cu2(cca)(phen)4 dimers, in which two copper(II) centers are bridged by a 4-carboxycinnamate ligand. Compound 2 consists of polymeric Cu2(OH)(oda)(phen)2 chains in which Cu2(OH)(phen)2 dimers are linked by bridging oda ligands. The compounds were evaluated for in vitro anticancer efficacy and were found to exhibit significant activities against human-derived pancreatic and liver cancer cells.

Original languageEnglish (US)
JournalTransition Metal Chemistry
DOIs
StateAccepted/In press - Jan 1 2018

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ASJC Scopus subject areas

  • Inorganic Chemistry
  • Metals and Alloys
  • Materials Chemistry

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