Synthesis, crystal structures and in vitro anticancer activities of two copper(II) coordination compounds

Helen Wang; Maurice Sorolla; Xiqu Wang; Allan J. Jacobson; Hongyu Wang; Anil K Pillai

doi:10.1007/s11243-018-0288-3

Synthesis, crystal structures and in vitro anticancer activities of two copper(II) coordination compounds

Helen Wang, Maurice Sorolla, Xiqu Wang, Allan J. Jacobson, Hongyu Wang, Anil K Pillai

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Two new Cu(II) coordination compounds, [Cu ₂ (cca)(phen) ₄ ](ClO ₄ ) ₂ (H ₂ O) _5.5 , 1, and [Cu ₂ (OH)(oda)(phen) ₂ )](ClO ₄ ), 2, where cca = 4-carboxycinnamate; phen = 1,10-phenanthroline; oda = octanedioate, have been synthesized and their structures determined by single-crystal X-ray diffraction. Compound 1 contains cationic Cu ₂ (cca)(phen) ₄ dimers, in which two copper(II) centers are bridged by a 4-carboxycinnamate ligand. Compound 2 consists of polymeric Cu ₂ (OH)(oda)(phen) ₂ chains in which Cu ₂ (OH)(phen) ₂ dimers are linked by bridging oda ligands. The compounds were evaluated for in vitro anticancer efficacy and were found to exhibit significant activities against human-derived pancreatic and liver cancer cells.

Original language	English (US)
Pages (from-to)	237-245
Number of pages	9
Journal	Transition Metal Chemistry
Volume	44
Issue number	3
DOIs	https://doi.org/10.1007/s11243-018-0288-3
State	Published - Apr 15 2019

ASJC Scopus subject areas

Inorganic Chemistry
Metals and Alloys
Materials Chemistry

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@article{60ea5906711746b7b4b2e63fa29c808c,

title = "Synthesis, crystal structures and in vitro anticancer activities of two copper(II) coordination compounds",

abstract = " Two new Cu(II) coordination compounds, [Cu 2 (cca)(phen) 4 ](ClO 4 ) 2 (H 2 O) 5.5 , 1, and [Cu 2 (OH)(oda)(phen) 2 )](ClO 4 ), 2, where cca = 4-carboxycinnamate; phen = 1,10-phenanthroline; oda = octanedioate, have been synthesized and their structures determined by single-crystal X-ray diffraction. Compound 1 contains cationic Cu 2 (cca)(phen) 4 dimers, in which two copper(II) centers are bridged by a 4-carboxycinnamate ligand. Compound 2 consists of polymeric Cu 2 (OH)(oda)(phen) 2 chains in which Cu 2 (OH)(phen) 2 dimers are linked by bridging oda ligands. The compounds were evaluated for in vitro anticancer efficacy and were found to exhibit significant activities against human-derived pancreatic and liver cancer cells. ",

author = "Helen Wang and Maurice Sorolla and Xiqu Wang and Jacobson, {Allan J.} and Hongyu Wang and Pillai, {Anil K}",

note = "Funding Information: Acknowledgements This work was supported by the R. A. Welch Foundation [Grant No. #E-0024]. Publisher Copyright: {\textcopyright} 2018, Springer Nature Switzerland AG.",

year = "2019",

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doi = "10.1007/s11243-018-0288-3",

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T1 - Synthesis, crystal structures and in vitro anticancer activities of two copper(II) coordination compounds

AU - Wang, Helen

AU - Sorolla, Maurice

AU - Wang, Xiqu

AU - Jacobson, Allan J.

AU - Wang, Hongyu

AU - Pillai, Anil K

PY - 2019/4/15

Y1 - 2019/4/15

N2 - Two new Cu(II) coordination compounds, [Cu 2 (cca)(phen) 4 ](ClO 4 ) 2 (H 2 O) 5.5 , 1, and [Cu 2 (OH)(oda)(phen) 2 )](ClO 4 ), 2, where cca = 4-carboxycinnamate; phen = 1,10-phenanthroline; oda = octanedioate, have been synthesized and their structures determined by single-crystal X-ray diffraction. Compound 1 contains cationic Cu 2 (cca)(phen) 4 dimers, in which two copper(II) centers are bridged by a 4-carboxycinnamate ligand. Compound 2 consists of polymeric Cu 2 (OH)(oda)(phen) 2 chains in which Cu 2 (OH)(phen) 2 dimers are linked by bridging oda ligands. The compounds were evaluated for in vitro anticancer efficacy and were found to exhibit significant activities against human-derived pancreatic and liver cancer cells.

AB - Two new Cu(II) coordination compounds, [Cu 2 (cca)(phen) 4 ](ClO 4 ) 2 (H 2 O) 5.5 , 1, and [Cu 2 (OH)(oda)(phen) 2 )](ClO 4 ), 2, where cca = 4-carboxycinnamate; phen = 1,10-phenanthroline; oda = octanedioate, have been synthesized and their structures determined by single-crystal X-ray diffraction. Compound 1 contains cationic Cu 2 (cca)(phen) 4 dimers, in which two copper(II) centers are bridged by a 4-carboxycinnamate ligand. Compound 2 consists of polymeric Cu 2 (OH)(oda)(phen) 2 chains in which Cu 2 (OH)(phen) 2 dimers are linked by bridging oda ligands. The compounds were evaluated for in vitro anticancer efficacy and were found to exhibit significant activities against human-derived pancreatic and liver cancer cells.

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JO - Transition Metal Chemistry

JF - Transition Metal Chemistry

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ER -

Synthesis, crystal structures and in vitro anticancer activities of two copper(II) coordination compounds

Abstract

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