Synthesis, crystal structures and in vitro anticancer activities of two copper(II) coordination compounds

Helen Wang, Maurice Sorolla, Xiqu Wang, Allan J. Jacobson, Hongyu Wang, Anil K Pillai

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Two new Cu(II) coordination compounds, [Cu 2 (cca)(phen) 4 ](ClO 4 ) 2 (H 2 O) 5.5 , 1, and [Cu 2 (OH)(oda)(phen) 2 )](ClO 4 ), 2, where cca = 4-carboxycinnamate; phen = 1,10-phenanthroline; oda = octanedioate, have been synthesized and their structures determined by single-crystal X-ray diffraction. Compound 1 contains cationic Cu 2 (cca)(phen) 4 dimers, in which two copper(II) centers are bridged by a 4-carboxycinnamate ligand. Compound 2 consists of polymeric Cu 2 (OH)(oda)(phen) 2 chains in which Cu 2 (OH)(phen) 2 dimers are linked by bridging oda ligands. The compounds were evaluated for in vitro anticancer efficacy and were found to exhibit significant activities against human-derived pancreatic and liver cancer cells.

Original languageEnglish (US)
Pages (from-to)237-245
Number of pages9
JournalTransition Metal Chemistry
Volume44
Issue number3
DOIs
StatePublished - Apr 15 2019

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Metals and Alloys
  • Materials Chemistry

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