Synthesis of biologically active biotinylated muramyl dipeptides

Catherine Leimkuhler Grimes, Daniel K. Podolsky, Erin K. O'Shea

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Muramyl dipeptide (MDP) is believed to interact with an innate immune receptor, Nod2. To identify the cellular receptor for MDP, we have synthesized biotinylated MDP isomers and tested the ability of these compounds to activate Nod2 in a cell-based assay. We found that the modification of MDP does not perturb its ability to activate Nod2. These tagged versions of MDP will be useful to identify the cellular receptor of the immunostimulatory molecules.

Original languageEnglish (US)
Pages (from-to)6061-6063
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number20
DOIs
StatePublished - Oct 1 2010

Keywords

  • Affinity reagent
  • Innate immunity
  • Muramyl dipeptide
  • Nod2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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