Abstract
Charette asymmetric cyclopropanation, chiral thiazoline synthesis by thioamide cyclization under modified Mitsunobu conditions, Ti(iPrO)4/bi-naphthol catalyzed allylstannane addition, and an exceptionally mild two-carbon homologation via dehydrative alkylation with phenylsulfonylacetonitrile/Ph3P/ADDP convened in an efficient, stereocontrolled route to the title bioactive heterocycle.
Original language | English (US) |
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Pages (from-to) | 7167-7170 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 37 |
Issue number | 40 |
DOIs | |
State | Published - Sep 30 1996 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry