Synthesis of curacin A, an antimitotic cyclopropane-thiazoline from the marine cyanobacterium Lyngbya majuscula

Jing Yu Lai, Jurong Yu, Belew Mekonnen, J. R. Falck

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Charette asymmetric cyclopropanation, chiral thiazoline synthesis by thioamide cyclization under modified Mitsunobu conditions, Ti(iPrO)4/bi-naphthol catalyzed allylstannane addition, and an exceptionally mild two-carbon homologation via dehydrative alkylation with phenylsulfonylacetonitrile/Ph3P/ADDP convened in an efficient, stereocontrolled route to the title bioactive heterocycle.

Original languageEnglish (US)
Pages (from-to)7167-7170
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number40
DOIs
StatePublished - Sep 30 1996

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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