Synthesis of fluoro- and perfluoroalkyl arenes via palladium-catalyzed [4 + 2] benzannulation reaction

Olga V. Zatolochnaya, Vladimir Gevorgyan

Research output: Contribution to journalArticle

32 Scopus citations


An efficient entry into densely substituted fluorinated and perfluoroalkylated benzene derivatives via chemo- and regioselective Pd-catalyzed [4 + 2] cross-benzannulation is presented. The synthetic utility of these products for the synthesis of various aromatic and heteroaromatic compounds is also demonstrated. This strategy offers a viable and quite general alternative to existing fluorination and perfluoroalkylation methods for securing these valuable molecules.

Original languageEnglish (US)
Pages (from-to)2562-2565
Number of pages4
JournalOrganic Letters
Issue number10
StatePublished - May 17 2013


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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