Synthesis of (±)-hepoxilin A3 utilizing arsonium ylides

P. Chabert, C. Mioskowski, J. R. Falck

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

(±)-Hepoxilin A3, a biologically active metabolite of arachidonic acid, was prepared from 1-heptyne and δ-valerolactone by a simple, convergent strategy that exploits arosnium ylides for homologation/functionalization.

Original languageEnglish (US)
Pages (from-to)2545-2548
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number19
DOIs
StatePublished - 1989

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Metabolites
Arachidonic Acid
8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of (±)-hepoxilin A3 utilizing arsonium ylides. / Chabert, P.; Mioskowski, C.; Falck, J. R.

In: Tetrahedron Letters, Vol. 30, No. 19, 1989, p. 2545-2548.

Research output: Contribution to journalArticle

Chabert, P. ; Mioskowski, C. ; Falck, J. R. / Synthesis of (±)-hepoxilin A3 utilizing arsonium ylides. In: Tetrahedron Letters. 1989 ; Vol. 30, No. 19. pp. 2545-2548.
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