Synthesis of novel estrone analogs by incorporation of thiophenols via conjugate addition to an enone side chain

Lucas C. Kopel, Mahmoud S. Ahmed, Fathi T. Halaweish

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Functionalized estrogen analogs have received interest due to their unique and differing biological activity compared to their parent compounds. The synthesis of a new class of 3-methoxyestrone analogs functionalized at the C17 position possessing both alkyl and aryl substituted α,β-unsaturated ketones is described, along with their thiophenol conjugate addition products.

Original languageEnglish (US)
Pages (from-to)1119-1125
Number of pages7
JournalSteroids
Volume78
Issue number11
DOIs
StatePublished - Aug 30 2013
Externally publishedYes

Fingerprint

Estradiol Congeners
Estrone
Bioactivity
Ketones
thiophenol

Keywords

  • Aldol
  • Enone
  • Estrone
  • Sulfa-Michael addition
  • Thiol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Synthesis of novel estrone analogs by incorporation of thiophenols via conjugate addition to an enone side chain. / Kopel, Lucas C.; Ahmed, Mahmoud S.; Halaweish, Fathi T.

In: Steroids, Vol. 78, No. 11, 30.08.2013, p. 1119-1125.

Research output: Contribution to journalArticle

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