Synthesis of oligonucleotide-peptide and oligonucleotide-protein conjugates.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The conjugation of macromolecules offers a rapid and versatile route to improved function. Here, the methods for obtaining disulfide-linked oligonucleotide-peptide and oligonucleotide-protein conjugates are described. These hybrid molecules can be used deliver chemical functionality to specific sequences within deoxyribonucleic acid and ribonucleic acid. The peptides and proteins can also be used to enhance the hybridization properties of the attached oligonucleotides.

Original languageEnglish (US)
Pages (from-to)197-206
Number of pages10
JournalMethods in molecular biology (Clifton, N.J.)
Volume283
StatePublished - 2004

Fingerprint

Oligonucleotides
Peptides
Proteins
Disulfides
RNA
DNA

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

@article{742030d090c1499dbdee63b78cf8ed6e,
title = "Synthesis of oligonucleotide-peptide and oligonucleotide-protein conjugates.",
abstract = "The conjugation of macromolecules offers a rapid and versatile route to improved function. Here, the methods for obtaining disulfide-linked oligonucleotide-peptide and oligonucleotide-protein conjugates are described. These hybrid molecules can be used deliver chemical functionality to specific sequences within deoxyribonucleic acid and ribonucleic acid. The peptides and proteins can also be used to enhance the hybridization properties of the attached oligonucleotides.",
author = "Corey, {David R.}",
year = "2004",
language = "English (US)",
volume = "283",
pages = "197--206",
journal = "Methods in molecular biology (Clifton, N.J.)",
issn = "1064-3745",
publisher = "Humana Press",

}

TY - JOUR

T1 - Synthesis of oligonucleotide-peptide and oligonucleotide-protein conjugates.

AU - Corey, David R.

PY - 2004

Y1 - 2004

N2 - The conjugation of macromolecules offers a rapid and versatile route to improved function. Here, the methods for obtaining disulfide-linked oligonucleotide-peptide and oligonucleotide-protein conjugates are described. These hybrid molecules can be used deliver chemical functionality to specific sequences within deoxyribonucleic acid and ribonucleic acid. The peptides and proteins can also be used to enhance the hybridization properties of the attached oligonucleotides.

AB - The conjugation of macromolecules offers a rapid and versatile route to improved function. Here, the methods for obtaining disulfide-linked oligonucleotide-peptide and oligonucleotide-protein conjugates are described. These hybrid molecules can be used deliver chemical functionality to specific sequences within deoxyribonucleic acid and ribonucleic acid. The peptides and proteins can also be used to enhance the hybridization properties of the attached oligonucleotides.

UR - http://www.scopus.com/inward/record.url?scp=4644329085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644329085&partnerID=8YFLogxK

M3 - Article

VL - 283

SP - 197

EP - 206

JO - Methods in molecular biology (Clifton, N.J.)

JF - Methods in molecular biology (Clifton, N.J.)

SN - 1064-3745

ER -