Synthesis of oligonucleotide-peptide and oligonucleotide-protein conjugates.

David R. Corey

doi:10.1385/1-59259-813-7:197

Synthesis of oligonucleotide-peptide and oligonucleotide-protein conjugates.

David R. Corey

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The conjugation of macromolecules offers a rapid and versatile route to improved function. Here, the methods for obtaining disulfide-linked oligonucleotide-peptide and oligonucleotide-protein conjugates are described. These hybrid molecules can be used deliver chemical functionality to specific sequences within deoxyribonucleic acid and ribonucleic acid. The peptides and proteins can also be used to enhance the hybridization properties of the attached oligonucleotides.

Original language	English (US)
Pages (from-to)	197-206
Number of pages	10
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	283
DOIs	https://doi.org/10.1385/1-59259-813-7:197
State	Published - 2004

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1385/1-59259-813-7:197

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AB - The conjugation of macromolecules offers a rapid and versatile route to improved function. Here, the methods for obtaining disulfide-linked oligonucleotide-peptide and oligonucleotide-protein conjugates are described. These hybrid molecules can be used deliver chemical functionality to specific sequences within deoxyribonucleic acid and ribonucleic acid. The peptides and proteins can also be used to enhance the hybridization properties of the attached oligonucleotides.

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Synthesis of oligonucleotide-peptide and oligonucleotide-protein conjugates.

Abstract

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