(formuld presented) A convergent, stereoselective assembly of the C1-C21 (C1′-C21′) fragment of SCH 351448, a 28-membered bis-lactone natural product, has been developed. A highly efficient approach to this fragment assembles 75% of the carbon skeleton and all the stereochemical elements present in the natural product. In addition, an interesting boron ligand effect on the diastereoselectivity of a key aldol reaction with methyl ketone-derived enolborinates is reported.
ASJC Scopus subject areas
- Molecular Medicine