Abstract
(formuld presented) A convergent, stereoselective assembly of the C1-C21 (C1′-C21′) fragment of SCH 351448, a 28-membered bis-lactone natural product, has been developed. A highly efficient approach to this fragment assembles 75% of the carbon skeleton and all the stereochemical elements present in the natural product. In addition, an interesting boron ligand effect on the diastereoselectivity of a key aldol reaction with methyl ketone-derived enolborinates is reported.
Original language | English (US) |
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Pages (from-to) | 481-484 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Feb 21 2002 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry