Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting

J. E. Wilson, R. C. Eberhart, A. B. Elkowitz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Gamma rays from 60Co were used to graft chloromethylstyrene on samples of polysilicone, followed by quaternization with pyridine, then reaction with sodium heparin to replace chloride ions in the samples with heparin anions. Extraction tests on the heparinized samples with normal saline solution showed a maximum heparin removal rate of 5 x 10-8 g/cm2/min. The heparinized polysilicone was found to be more blood compatible than untreated polysilicone in a rabbit ex vivo bleeding test.

Original languageEnglish (US)
Pages (from-to)769-782
Number of pages14
JournalJournal of Macromolecular Science: Part A - Chemistry
Volume16
Issue number4
DOIs
StatePublished - 1981

Fingerprint

Heparin
Radiation
Sodium Chloride
Grafts
Gamma rays
Pyridine
Anions
Chlorides
Blood
Negative ions
Ions
pyridine
chloromethylstyrene

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry
  • Ceramics and Composites

Cite this

Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting. / Wilson, J. E.; Eberhart, R. C.; Elkowitz, A. B.

In: Journal of Macromolecular Science: Part A - Chemistry, Vol. 16, No. 4, 1981, p. 769-782.

Research output: Contribution to journalArticle

Wilson, J. E. ; Eberhart, R. C. ; Elkowitz, A. B. / Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting. In: Journal of Macromolecular Science: Part A - Chemistry. 1981 ; Vol. 16, No. 4. pp. 769-782.
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