Synthesis, structure, and anticancer activity of gallium(III) complexes with asymmetric tridentate ligands: Growth inhibition and apoptosis induction of cisplatin-resistant neuroblastoma cells

Rajendra Shakya, Fangyu Peng, Jianguo Liu, Mary Jane Heeg, Claudio N. Verani

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Five gallium(III) complexes described as [GaIII(L X)2]CIO4, where (LX)- is the deprotonated form of a series of asymmetric ligands containing pyridine and 4,6-substituted phenol moieties, were synthesized and characterized by spectroscopic and spectrometric methods. Phenol substituents encompass the electron-withdrawing and electron-donating methoxy (1), nitro (2), chloro (3), bromo (4), and iodo (5) groups. Complexes 1 and 3 have had their molecular structure solved by X-ray crystallography and show distinct coordination modes. Complexes 1-5 were tested for growth-inhibition activity on cisplatin-resistant human neuroblastoma cells; those containing halogen substituents on the phenolate rings, i.e., 3-5, showed activity superior to that observed for cisplatin and induced apoptosis of neuroblastoma cells. Nitro-containing 2 suppressed proliferation of the neuroblastoma cells but induced apoptosis less effectively.

Original languageEnglish (US)
Pages (from-to)6263-6268
Number of pages6
JournalInorganic Chemistry
Issue number16
StatePublished - Aug 7 2006


ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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