@inproceedings{2123b64ba202494fb168a8f4e95f9b21,
title = "Synthesize dye-bioconjugates to visualize cancer cells using fluorescence microscopy",
abstract = "The clinical diagnosis of most cancers is based on evaluation of histology microscopic slide to view the size and shape of cellular nuclei, and morphological structure of tissue. To achieve this goal in vivo and in deep tissue, near infrared (NIR) dyes-bovine serum albumin (BSA) and immunoglobulin G (IgG) conjugates were synthesized. The spectral study show that the absorption and fluorescence of the dye-conjugates are in the {"}tissue optical window{"} between 650 nm and 1100 nm. The internalization and pinocytosis of the synthesized compound were investigated in cell level using fluorescence microscopy to obtain the optimal concentration and staining time scale.",
keywords = "Near infrared (NIR), dye-bioconjugates, fluorescence microscopy, prostate cancer cell lines",
author = "Yang Pu and Rui Tang and Jianpeng Xue and Wang, {W. B.} and Baogang Xu and Duanwen Shen and Sharon Bloch and Mingzhou Zhou and S. Achilefu and Alfano, {R. R.}",
year = "2013",
doi = "10.1117/12.2000080",
language = "English (US)",
isbn = "9780819493569",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI",
note = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI ; Conference date: 02-02-2013 Through 05-02-2013",
}