Synthetic molecules as antibody replacements

Thomas Kodadek, M. Muralidhar Reddy, Hernando J. Olivos, Kiran Bachhawat-Sikder, Prasanna G. Alluri

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Antibodies are by far the most versatile, valuable, and widely used protein-binding agents. They are essential tools in biological research and are increasingly being developed as therapeutic reagents. However, antibodies have a number of practical limitations, and it would be desirable in many applications to replace them with simpler, more robust synthetic molecules. Unfortunately, synthetic protein-binding agents rarely exhibit the high affinity and specificity typical of a good antibody. This article reviews efforts to overcome these limitations and to develop a facile, high-throughput methodology for the isolation of synthetic protein ligands with antibody-like binding characteristics.

Original languageEnglish (US)
Pages (from-to)711-718
Number of pages8
JournalAccounts of Chemical Research
Volume37
Issue number9
DOIs
StatePublished - Sep 1 2004

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Molecules
Antibodies
Throughput
Ligands
Proteins
Protein Binding

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Kodadek, T., Reddy, M. M., Olivos, H. J., Bachhawat-Sikder, K., & Alluri, P. G. (2004). Synthetic molecules as antibody replacements. Accounts of Chemical Research, 37(9), 711-718. https://doi.org/10.1021/ar030145l

Synthetic molecules as antibody replacements. / Kodadek, Thomas; Reddy, M. Muralidhar; Olivos, Hernando J.; Bachhawat-Sikder, Kiran; Alluri, Prasanna G.

In: Accounts of Chemical Research, Vol. 37, No. 9, 01.09.2004, p. 711-718.

Research output: Contribution to journalArticle

Kodadek, T, Reddy, MM, Olivos, HJ, Bachhawat-Sikder, K & Alluri, PG 2004, 'Synthetic molecules as antibody replacements', Accounts of Chemical Research, vol. 37, no. 9, pp. 711-718. https://doi.org/10.1021/ar030145l
Kodadek T, Reddy MM, Olivos HJ, Bachhawat-Sikder K, Alluri PG. Synthetic molecules as antibody replacements. Accounts of Chemical Research. 2004 Sep 1;37(9):711-718. https://doi.org/10.1021/ar030145l
Kodadek, Thomas ; Reddy, M. Muralidhar ; Olivos, Hernando J. ; Bachhawat-Sikder, Kiran ; Alluri, Prasanna G. / Synthetic molecules as antibody replacements. In: Accounts of Chemical Research. 2004 ; Vol. 37, No. 9. pp. 711-718.
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