Synthetic molecules as antibody replacements

Thomas Kodadek, M. Muralidhar Reddy, Hernando J. Olivos, Kiran Bachhawat-Sikder, Prasanna G. Alluri

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Antibodies are by far the most versatile, valuable, and widely used protein-binding agents. They are essential tools in biological research and are increasingly being developed as therapeutic reagents. However, antibodies have a number of practical limitations, and it would be desirable in many applications to replace them with simpler, more robust synthetic molecules. Unfortunately, synthetic protein-binding agents rarely exhibit the high affinity and specificity typical of a good antibody. This article reviews efforts to overcome these limitations and to develop a facile, high-throughput methodology for the isolation of synthetic protein ligands with antibody-like binding characteristics.

Original languageEnglish (US)
Pages (from-to)711-718
Number of pages8
JournalAccounts of Chemical Research
Volume37
Issue number9
DOIs
StatePublished - Sep 2004

ASJC Scopus subject areas

  • Chemistry(all)

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